Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: Example: Benzene, CAS: 71-43-2

The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6)...

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Bibliographic Details
Published in:Food and chemical toxicology 2010, Vol.48, p.S49-S56
Main Authors: Smith, Benjamin, Cadby, Peter, DiNovi, Michael, Setzer, R. Woodrow
Format: Article
Language:English
Subjects:
Animals
benzene
Benzene - toxicity
Benzene Derivatives - toxicity
carcinogenicity
Carcinogens - toxicity
Data Interpretation, Statistical
Diet
dietary exposure
dose response
Dose-Response Relationship, Drug
experts
Female
food analysis
food composition
food contamination
Food Contamination - analysis
genotoxicity
health effects assessments
Humans
International Life Sciences Institute - European branch (ILSI Europe)
Male
margin of exposure (MOE) approach
methodology
Mice
Models, Statistical
Mutagens - toxicity
Neoplasms - chemically induced
Neoplasms - epidemiology
Rats
risk assessment
toxic substances
toxicity
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Summary:The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6) depending on the assumptions used in the exposure estimation.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2009.10.015