Contrast-induced nephropathy in patients with type 2 diabetes during coronary angiography: Risk-factors and prognostic value

Abstract Aims To determine risk factors, prognostic, value prevention of development of contrastinduced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with type 2 diabetes mellitus (T2DM). Materials and Methods We have retrospectively analyzed the incidence of CIN devel...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2009-12, Vol.86, p.S63-S69
Main Authors: Zaytseva, Natalia V, Shamkhalova, Minara S, Shestakova, Marina V, Matskeplishvili, Simon T, Tugeeva, Elvina F, Buziashvili, Ury I, Deev, Alexandr D, Dedov, Ivan I
Format: Article
Language:English
Subjects:
Contrast Media - adverse effects
Contrast-induced nephropathy
Coronary angiography
Coronary Angiography - adverse effects
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnostic imaging
Diabetes Mellitus, Type 2 - physiopathology
Diabetic Nephropathies - epidemiology
Endocrinology & Metabolism
Female
Humans
Lipids - blood
Male
Middle Aged
Prognosis
Prognostic significance
Retrospective Studies
Risk Assessment
Risk Factors
Stroke Volume
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Summary:Abstract Aims To determine risk factors, prognostic, value prevention of development of contrastinduced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with type 2 diabetes mellitus (T2DM). Materials and Methods We have retrospectively analyzed the incidence of CIN developed after PCI in 151 patients T2DM and 50 patients without diabetes. All patients were subjected to thorough clinical examination (including serum creatinine level before and 48 hours after intervention). Results CIN developed more frequently after PCI in patients with T2DM than in patients of the same age without diabetes at the same baseline renal function, volume of contrast media and hydration status. The risk of developing CIN in patients with T2DM is associated with: heart failure, anemia, volume of contrast media, diuretics use in the peri-procedure period, multiple coronary artery disease, need of interventional procedures. TIDM patients with CIN had faster decline of renal function, more often developed cardiovascular diseases and had lower 24 month survival rate. Conclusions High risk of CIN development and its prognostic significance in patients with T2DM determine the necessity of individually evaluated risks for preventive measures during contrast media interventions.
ISSN:0168-8227
1872-8227
DOI:10.1016/S0168-8227(09)70012-9