The effect of different hypertension models on active avoidance learning

This study tested the effects of different hypertension models on active avoidance learning in rats. Three-month-old male Wistar rats were divided randomly into six groups as follows: control (C), sham operated (sham), two kidney-one clip (2K-1C), one kidney-one clip (1K-1C), deoxycorticosterone-sal...

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Bibliographic Details
Published in:Brain and cognition 2003-07, Vol.52 (2), p.216-222
Main Authors: Hacioglu, Gulay, Agar, Aysel, Ozkaya, Gul, Yargicoglu, Piraye, Gumuslu, Saadet
Format: Article
Language:English
Subjects:
Active avoidance
Animal
Animals
Avoidance Learning
Biological and medical sciences
Brain - metabolism
Brain - physiopathology
Conditioning
Different hypertension models
Fundamental and applied biological sciences. Psychology
Hippocampus - metabolism
Hippocampus - physiopathology
Hypertension - physiopathology
Learning
Learning. Memory
Lipid Peroxidation
Male
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Random Allocation
Rat
Rats
Rats, Wistar
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Summary:This study tested the effects of different hypertension models on active avoidance learning in rats. Three-month-old male Wistar rats were divided randomly into six groups as follows: control (C), sham operated (sham), two kidney-one clip (2K-1C), one kidney-one clip (1K-1C), deoxycorticosterone-salt (DOCA), and N-ω-nitro- l-arginine-methyl ester ( l-NAME) groups. Mean arterial blood pressures were significantly higher in four hypertensive groups compared with control and sham groups. The active avoidance training results indicated that hypertension state is associated with learning impairment. Thiobarbituric acid-reactive substances (TBARS) were determined as an indicator of lipid peroxidation in brain and hippocampus. Additionally, brain and hippocampus nitrite levels were studied.
ISSN:0278-2626
1090-2147
DOI:10.1016/S0278-2626(03)00072-1