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Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis
Background and Aims: To explore the protecting effects and mechanisms of dexamethasone on spleen injury in rats with severe acute pancreatitis (SAP). Methods: The rats were randomly divided into a model control group, treated group and sham‐operated group. The contents of plasma endotoxin, serum N...
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| Published in: | Journal of gastroenterology and hepatology 2010-02, Vol.25 (2), p.302-308 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Xiping, Zhang Ruiping, Zhang Binyan, Yu Li, Zhou Hanqing, Chen Wei, Zhu Rongchao, Ying Jing, Ye Wenqin, Yuan Jinjin, Bai |
| description | Background and Aims: To explore the protecting effects and mechanisms of dexamethasone on spleen injury in rats with severe acute pancreatitis (SAP).
Methods: The rats were randomly divided into a model control group, treated group and sham‐operated group. The contents of plasma endotoxin, serum NO, phospholipase A2 enzyme (PLA2) and endothelin‐1 (ET‐1) were determined. The mortality rate, pathological changes and changes of Bax and Bcl‐2 protein expression levels and apoptotic indexes in the spleen of rats were observed in all groups, respectively, at 3, 6 and 12 h after operation.
Results: Although the survival rate was significantly higher in the treated group than in the model control group, there was no significantly different between them (P > 0.05). The expression levels of Bax and Bcl‐2 proteins and apoptotic indexes were significantly higher in the treated group than in the model control group at different time points (P |
| doi_str_mv | 10.1111/j.1440-1746.2009.05999.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733907226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733907226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4369-b102945ef1746555c6e81c03cab2a74dcacca55202e6d3e2906467484188c73e3</originalsourceid><addsrcrecordid>eNqNkE9v0zAYhy0EYmXwFZAviFOC_8bxgQOaWAuaBhJFQ1ws13mzuUuTYjtb--1x1qpc8cWv7ednv34QwpSUNI8P65IKQQqqRFUyQnRJpNa63D1Ds9PBczQjNZWF5lSfoVcxrgkhgij5Ep1RXSshBJuh--9hSOCS728xtG2uIh5abHFnwy3gZogwrRvY2Q2kOxuHPm_0OG47gB77fj2G_UQEm5OPPt3hCA8QAFs3JsBb27sANvnk42v0orVdhDfH-Rz9vPy8vFgUV9_mXy4-XRVO8EoXK0qYFhLa6RdSSldBTR3hzq6YVaJx1jkrJSMMqoYD06QSlRK1oHXtFAd-jt4f7t2G4c8IMZmNjw66zvYwjNEozjVRjFWZrA-kC0OMAVqzDX5jw95QYibTZm0moWZqxUymzZNps8vRt8dHxtUGmn_Bo9oMvDsCNjrbtSGb8PHEMSa4VlJn7uOBe_Qd7P-7AfN1vpiqnC8OeR8T7E55G-5NpbiS5uZ6bm7qxfLH8vcvo_lfpA-pbA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733907226</pqid></control><display><type>article</type><title>Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Xiping, Zhang ; Ruiping, Zhang ; Binyan, Yu ; Li, Zhou ; Hanqing, Chen ; Wei, Zhu ; Rongchao, Ying ; Jing, Ye ; Wenqin, Yuan ; Jinjin, Bai</creator><creatorcontrib>Xiping, Zhang ; Ruiping, Zhang ; Binyan, Yu ; Li, Zhou ; Hanqing, Chen ; Wei, Zhu ; Rongchao, Ying ; Jing, Ye ; Wenqin, Yuan ; Jinjin, Bai</creatorcontrib><description>Background and Aims: To explore the protecting effects and mechanisms of dexamethasone on spleen injury in rats with severe acute pancreatitis (SAP).
Methods: The rats were randomly divided into a model control group, treated group and sham‐operated group. The contents of plasma endotoxin, serum NO, phospholipase A2 enzyme (PLA2) and endothelin‐1 (ET‐1) were determined. The mortality rate, pathological changes and changes of Bax and Bcl‐2 protein expression levels and apoptotic indexes in the spleen of rats were observed in all groups, respectively, at 3, 6 and 12 h after operation.
Results: Although the survival rate was significantly higher in the treated group than in the model control group, there was no significantly different between them (P > 0.05). The expression levels of Bax and Bcl‐2 proteins and apoptotic indexes were significantly higher in the treated group than in the model control group at different time points (P < 0.05 or P < 0.01) while other blood indexes contents and pathological severity scores of spleen were significantly lower in the treated group than in the model control group (P < 0.05, P < 0.01 or P < 0.001).
Conclusion: Dexamethasone can protect spleen from injury during SAP mainly by reducing the content of inflammatory mediators in blood.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.2009.05999.x</identifier><identifier>PMID: 19874442</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Acute Disease ; Animals ; Anti-Inflammatory Agents - administration & dosage ; apoptosis ; Apoptosis - drug effects ; bcl-2-Associated X Protein - metabolism ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; dexamethasone ; Dexamethasone - administration & dosage ; Disease Models, Animal ; Endothelin-1 - blood ; Endotoxins - blood ; Gastroenterology. Liver. Pancreas. Abdomen ; Inflammation Mediators - blood ; Injuries of the abdomen. Foreign bodies of the digestive system ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Nitric Oxide - blood ; Other diseases. Semiology ; Pancreatitis - chemically induced ; Pancreatitis - complications ; Pancreatitis - drug therapy ; Pancreatitis - metabolism ; Pancreatitis - pathology ; Pharmacology. Drug treatments ; Phospholipases A2 - blood ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Rats ; Rats, Sprague-Dawley ; severe acute pancreatitis ; Severity of Illness Index ; spleen ; Spleen - drug effects ; Spleen - metabolism ; Spleen - pathology ; Splenic Diseases - etiology ; Splenic Diseases - metabolism ; Splenic Diseases - pathology ; Splenic Diseases - prevention & control ; Taurocholic Acid ; Time Factors ; tissue microarrays ; Traumas. Diseases due to physical agents</subject><ispartof>Journal of gastroenterology and hepatology, 2010-02, Vol.25 (2), p.302-308</ispartof><rights>2009 The Authors. Journal compilation © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4369-b102945ef1746555c6e81c03cab2a74dcacca55202e6d3e2906467484188c73e3</citedby><cites>FETCH-LOGICAL-c4369-b102945ef1746555c6e81c03cab2a74dcacca55202e6d3e2906467484188c73e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22439759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19874442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiping, Zhang</creatorcontrib><creatorcontrib>Ruiping, Zhang</creatorcontrib><creatorcontrib>Binyan, Yu</creatorcontrib><creatorcontrib>Li, Zhou</creatorcontrib><creatorcontrib>Hanqing, Chen</creatorcontrib><creatorcontrib>Wei, Zhu</creatorcontrib><creatorcontrib>Rongchao, Ying</creatorcontrib><creatorcontrib>Jing, Ye</creatorcontrib><creatorcontrib>Wenqin, Yuan</creatorcontrib><creatorcontrib>Jinjin, Bai</creatorcontrib><title>Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aims: To explore the protecting effects and mechanisms of dexamethasone on spleen injury in rats with severe acute pancreatitis (SAP).
Methods: The rats were randomly divided into a model control group, treated group and sham‐operated group. The contents of plasma endotoxin, serum NO, phospholipase A2 enzyme (PLA2) and endothelin‐1 (ET‐1) were determined. The mortality rate, pathological changes and changes of Bax and Bcl‐2 protein expression levels and apoptotic indexes in the spleen of rats were observed in all groups, respectively, at 3, 6 and 12 h after operation.
Results: Although the survival rate was significantly higher in the treated group than in the model control group, there was no significantly different between them (P > 0.05). The expression levels of Bax and Bcl‐2 proteins and apoptotic indexes were significantly higher in the treated group than in the model control group at different time points (P < 0.05 or P < 0.01) while other blood indexes contents and pathological severity scores of spleen were significantly lower in the treated group than in the model control group (P < 0.05, P < 0.01 or P < 0.001).
Conclusion: Dexamethasone can protect spleen from injury during SAP mainly by reducing the content of inflammatory mediators in blood.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>dexamethasone</subject><subject>Dexamethasone - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Endothelin-1 - blood</subject><subject>Endotoxins - blood</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Inflammation Mediators - blood</subject><subject>Injuries of the abdomen. Foreign bodies of the digestive system</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitric Oxide - blood</subject><subject>Other diseases. Semiology</subject><subject>Pancreatitis - chemically induced</subject><subject>Pancreatitis - complications</subject><subject>Pancreatitis - drug therapy</subject><subject>Pancreatitis - metabolism</subject><subject>Pancreatitis - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phospholipases A2 - blood</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>severe acute pancreatitis</subject><subject>Severity of Illness Index</subject><subject>spleen</subject><subject>Spleen - drug effects</subject><subject>Spleen - metabolism</subject><subject>Spleen - pathology</subject><subject>Splenic Diseases - etiology</subject><subject>Splenic Diseases - metabolism</subject><subject>Splenic Diseases - pathology</subject><subject>Splenic Diseases - prevention & control</subject><subject>Taurocholic Acid</subject><subject>Time Factors</subject><subject>tissue microarrays</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkE9v0zAYhy0EYmXwFZAviFOC_8bxgQOaWAuaBhJFQ1ws13mzuUuTYjtb--1x1qpc8cWv7ednv34QwpSUNI8P65IKQQqqRFUyQnRJpNa63D1Ds9PBczQjNZWF5lSfoVcxrgkhgij5Ep1RXSshBJuh--9hSOCS728xtG2uIh5abHFnwy3gZogwrRvY2Q2kOxuHPm_0OG47gB77fj2G_UQEm5OPPt3hCA8QAFs3JsBb27sANvnk42v0orVdhDfH-Rz9vPy8vFgUV9_mXy4-XRVO8EoXK0qYFhLa6RdSSldBTR3hzq6YVaJx1jkrJSMMqoYD06QSlRK1oHXtFAd-jt4f7t2G4c8IMZmNjw66zvYwjNEozjVRjFWZrA-kC0OMAVqzDX5jw95QYibTZm0moWZqxUymzZNps8vRt8dHxtUGmn_Bo9oMvDsCNjrbtSGb8PHEMSa4VlJn7uOBe_Qd7P-7AfN1vpiqnC8OeR8T7E55G-5NpbiS5uZ6bm7qxfLH8vcvo_lfpA-pbA</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Xiping, Zhang</creator><creator>Ruiping, Zhang</creator><creator>Binyan, Yu</creator><creator>Li, Zhou</creator><creator>Hanqing, Chen</creator><creator>Wei, Zhu</creator><creator>Rongchao, Ying</creator><creator>Jing, Ye</creator><creator>Wenqin, Yuan</creator><creator>Jinjin, Bai</creator><general>Blackwell Publishing Asia</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201002</creationdate><title>Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis</title><author>Xiping, Zhang ; Ruiping, Zhang ; Binyan, Yu ; Li, Zhou ; Hanqing, Chen ; Wei, Zhu ; Rongchao, Ying ; Jing, Ye ; Wenqin, Yuan ; Jinjin, Bai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4369-b102945ef1746555c6e81c03cab2a74dcacca55202e6d3e2906467484188c73e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>dexamethasone</topic><topic>Dexamethasone - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Endothelin-1 - blood</topic><topic>Endotoxins - blood</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Inflammation Mediators - blood</topic><topic>Injuries of the abdomen. Foreign bodies of the digestive system</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitric Oxide - blood</topic><topic>Other diseases. Semiology</topic><topic>Pancreatitis - chemically induced</topic><topic>Pancreatitis - complications</topic><topic>Pancreatitis - drug therapy</topic><topic>Pancreatitis - metabolism</topic><topic>Pancreatitis - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phospholipases A2 - blood</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>severe acute pancreatitis</topic><topic>Severity of Illness Index</topic><topic>spleen</topic><topic>Spleen - drug effects</topic><topic>Spleen - metabolism</topic><topic>Spleen - pathology</topic><topic>Splenic Diseases - etiology</topic><topic>Splenic Diseases - metabolism</topic><topic>Splenic Diseases - pathology</topic><topic>Splenic Diseases - prevention & control</topic><topic>Taurocholic Acid</topic><topic>Time Factors</topic><topic>tissue microarrays</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiping, Zhang</creatorcontrib><creatorcontrib>Ruiping, Zhang</creatorcontrib><creatorcontrib>Binyan, Yu</creatorcontrib><creatorcontrib>Li, Zhou</creatorcontrib><creatorcontrib>Hanqing, Chen</creatorcontrib><creatorcontrib>Wei, Zhu</creatorcontrib><creatorcontrib>Rongchao, Ying</creatorcontrib><creatorcontrib>Jing, Ye</creatorcontrib><creatorcontrib>Wenqin, Yuan</creatorcontrib><creatorcontrib>Jinjin, Bai</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiping, Zhang</au><au>Ruiping, Zhang</au><au>Binyan, Yu</au><au>Li, Zhou</au><au>Hanqing, Chen</au><au>Wei, Zhu</au><au>Rongchao, Ying</au><au>Jing, Ye</au><au>Wenqin, Yuan</au><au>Jinjin, Bai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2010-02</date><risdate>2010</risdate><volume>25</volume><issue>2</issue><spage>302</spage><epage>308</epage><pages>302-308</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aims: To explore the protecting effects and mechanisms of dexamethasone on spleen injury in rats with severe acute pancreatitis (SAP).
Methods: The rats were randomly divided into a model control group, treated group and sham‐operated group. The contents of plasma endotoxin, serum NO, phospholipase A2 enzyme (PLA2) and endothelin‐1 (ET‐1) were determined. The mortality rate, pathological changes and changes of Bax and Bcl‐2 protein expression levels and apoptotic indexes in the spleen of rats were observed in all groups, respectively, at 3, 6 and 12 h after operation.
Results: Although the survival rate was significantly higher in the treated group than in the model control group, there was no significantly different between them (P > 0.05). The expression levels of Bax and Bcl‐2 proteins and apoptotic indexes were significantly higher in the treated group than in the model control group at different time points (P < 0.05 or P < 0.01) while other blood indexes contents and pathological severity scores of spleen were significantly lower in the treated group than in the model control group (P < 0.05, P < 0.01 or P < 0.001).
Conclusion: Dexamethasone can protect spleen from injury during SAP mainly by reducing the content of inflammatory mediators in blood.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19874442</pmid><doi>10.1111/j.1440-1746.2009.05999.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute Disease Animals Anti-Inflammatory Agents - administration & dosage apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents dexamethasone Dexamethasone - administration & dosage Disease Models, Animal Endothelin-1 - blood Endotoxins - blood Gastroenterology. Liver. Pancreas. Abdomen Inflammation Mediators - blood Injuries of the abdomen. Foreign bodies of the digestive system Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Nitric Oxide - blood Other diseases. Semiology Pancreatitis - chemically induced Pancreatitis - complications Pancreatitis - drug therapy Pancreatitis - metabolism Pancreatitis - pathology Pharmacology. Drug treatments Phospholipases A2 - blood Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley severe acute pancreatitis Severity of Illness Index spleen Spleen - drug effects Spleen - metabolism Spleen - pathology Splenic Diseases - etiology Splenic Diseases - metabolism Splenic Diseases - pathology Splenic Diseases - prevention & control Taurocholic Acid Time Factors tissue microarrays Traumas. Diseases due to physical agents |
| title | Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis |
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