Current Surgical Management of Hilar and Intrahepatic Cholangiocarcinoma: The Role of Resection and Orthotopic Liver Transplantation

• Published in: Transplantation proceedings 2009-12, Vol.41 (10), p.4023-4035
• Main Authors: Petrowsky, H, Hong, J.C
• Format: Article
• Language: English
• Subjects: Bile Duct Neoplasms - epidemiology; Bile Duct Neoplasms - mortality; Bile Duct Neoplasms - pathology; Bile Duct Neoplasms - surgery; Bile Ducts, Intrahepatic - pathology; Bile Ducts, Intrahepatic - surgery; Cholangiocarcinoma - epidemiology; Cholangiocarcinoma - mortality; Cholangiocarcinoma - pathology; Cholangiocarcinoma - surgery; Embolization, Therapeutic; Humans; Incidence; Liver Transplantation - methods; Liver Transplantation - pathology; Portal Vein - pathology; Portal Vein - surgery; Surgery
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2009.11.001

Abstract Cholangiocarcinoma (CCA) is a rare but devastating malignancy that presents late, is notoriously difficult to diagnose, and is associated with a high mortality. Surgical resection is the only chance for cure or long-term survival. The treatment of CCA has remained challenging because of the lack of effective adjuvant therapy, aggressive nature of the disease, and critical location of the tumor in close proximity to vital structures such as the hepatic artery and the portal vein. Moreover, the operative approach is dictated by the location of the tumor and the presence of underlying liver disease. During the past 4 decades, the operative management of CCA has evolved from a treatment modality that primarily aimed at palliation to curative intent with an aggressive surgical approach to R0 resection and total hepatectomy followed by orthotopic liver transplantation.