Social and clinical determinants of quality of life in Parkinson's disease in a Russian cohort study

Abstract Parkinson's disease (PD) is a chronic neurodegenerative disorder that has a major impact on health and longevity in Eastern countries. Studies investigating health-related quality of life (HRQoL) in Eastern European and Asian countries are scarce. The objective of this cross-sectional...

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Published in:Parkinsonism & related disorders 2010-05, Vol.16 (4), p.243-248
Main Authors: Winter, Yaroslav, von Campenhausen, Sonja, Popov, Georgy, Reese, Jens P, Balzer-Geldsetzer, Monika, Kukshina, Anastasia, Zhukova, Tatyana V, Bertschi, Natalia, Bötzel, Kai, Gusev, Eugene, Oertel, Wolfgang H, Dodel, Richard, Guekht, Alla
Format: Article
Language:English
Subjects:
Activities of Daily Living
Aged
Cohort Studies
Cross-Sectional Studies
EQ-5D
Female
Humans
Male
Middle Aged
Neurology
Pain Measurement
Parkinson Disease - physiopathology
Parkinson Disease - psychology
Parkinson's disease
Quality of Life
Russia
Severity of Illness Index
Social Support
Surveys and Questionnaires
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Summary:Abstract Parkinson's disease (PD) is a chronic neurodegenerative disorder that has a major impact on health and longevity in Eastern countries. Studies investigating health-related quality of life (HRQoL) in Eastern European and Asian countries are scarce. The objective of this cross-sectional survey was to assess HRQoL in Russian patients with PD and identify its social and clinical determinants. The study included 100 outpatients with idiopathic PD and 100 controls. Patients were consecutively recruited from the neurological department of the Russian Medical State University in Moscow between October 2004 and December 2005. Regional healthy controls were matched for age and sex. The evaluation of HRQoL was performed using the EuroQol instrument (EQ-5D and EQ VAS). Disease severity was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS). Multivariate regression analyses were used to identify independent determinants of HRQoL. HRQoL was more notably decreased in PD patients than in controls (98% versus 74% of individuals with moderate or severe problems in at least one dimension of the EQ-5D ( p  
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2009.11.012