Urinary cannabinoid detection times after controlled oral administration of delta9-tetrahydrocannabinol to humans

Urinary cannabinoid excretion and immunoassay performance were evaluated by semiquantitative immunoassay and gas chromatography-mass spectrometry (GC/MS) analysis of metabolite concentrations in 4381 urine specimens collected before, during, and after controlled oral administration of tetrahydrocann...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2003-07, Vol.49 (7), p.1114-1124
Main Authors: Gustafson, Richard A, Levine, Barry, Stout, Peter R, Klette, Kevin L, George, M P, Moolchan, Eric T, Huestis, Marilyn A
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Cannabis
Double-Blind Method
Dronabinol - administration & dosage
Dronabinol - urine
Female
Gas Chromatography-Mass Spectrometry
Humans
Immunoassay
Male
Plant Oils - administration & dosage
Plant Oils - metabolism
Reference Values
Sensitivity and Specificity
Substance Abuse Detection - methods
Time Factors
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Summary:Urinary cannabinoid excretion and immunoassay performance were evaluated by semiquantitative immunoassay and gas chromatography-mass spectrometry (GC/MS) analysis of metabolite concentrations in 4381 urine specimens collected before, during, and after controlled oral administration of tetrahydrocannabinol (THC). Seven individuals received 0, 0.39, 0.47, 7.5, and 14.8 mg THC/day in this double-blind, placebo-controlled, randomized, clinical study conducted on a closed research ward. THC doses (hemp oils with various THC concentrations and the therapeutic drug Marinol) were administered three times daily for 5 days. All urine voids were collected over the 10-week study and later tested by Emit II, DRI, and CEDIA immunoassays and by GC/MS. Detection rates, detection times, and sensitivities, specificities, and efficiencies of the immunoassays were determined. At the federally mandated immunoassay cutoff (50 microg/L), mean detection rates were
ISSN:0009-9147