Role of melanin in the pathogenesis of cutaneous sporotrichosis

In this study, we evaluate the clinical, histopathological and ultra structural aspects of the infection by field strain (MEL +) and mutated strain (MEL −) of Sporothrix schenckii. The development of sporotrichosis at the inoculation sites was similar for both groups of animals after the second week...

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Bibliographic Details
Published in:Microbes and infection 2010-02, Vol.12 (2), p.162-165
Main Authors: Madrid, Isabel Martins, Xavier, Melissa O., Mattei, Antonella S., Fernandes, Cristina G., Guim, Thomaz N., Santin, Rosema, Schuch, Luiz Filipe D., Nobre, Márcia de Oliveira, Araújo Meireles, Mário Carlos
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Disease Models, Animal
Foot - microbiology
Foot - pathology
Fundamental and applied biological sciences. Psychology
Human mycoses
Infectious diseases
Liver - microbiology
Liver - pathology
Male
Medical sciences
Melanin
Melanins - genetics
Melanins - physiology
Microbiology
Miscellaneous
Mycology
Mycoses
Rats
Rats, Wistar
Skin - microbiology
Skin - pathology
Spleen - microbiology
Spleen - pathology
Sporothrix - isolation & purification
Sporothrix - metabolism
Sporothrix - pathogenicity
Sporothrix schenckii
Sporotrichosis
Sporotrichosis - microbiology
Sporotrichosis - pathology
Tropical mycoses
Virulence factors
Virulence Factors - physiology
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Summary:In this study, we evaluate the clinical, histopathological and ultra structural aspects of the infection by field strain (MEL +) and mutated strain (MEL −) of Sporothrix schenckii. The development of sporotrichosis at the inoculation sites was similar for both groups of animals after the second week of the experimental period. Statistical differences appeared only at weeks 3 and 5. The pigmented isolate had greater tissue invasive capacity, promoting the formation of multifocal granulomas, whereas the albino isolate induced an enhanced inflammatory response, restraining the agent to the core of the granulomas.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2009.10.004