The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss® : an experimental study in goats

Abstract Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2010-04, Vol.39 (4), p.371-378
Main Authors: Mooren, R.E.C.M, Dankers, A.C.A, Merkx, M.A.W, Bronkhorst, E.M, Jansen, J.A, Stoelinga, P.J.W
Format: Article
Language:English
Subjects:
Animals
autogenous bone graft
Biological and medical sciences
Bone Diseases - pathology
Bone Diseases - surgery
Bone Matrix - transplantation
Bone Regeneration - physiology
Bone Substitutes - therapeutic use
Bone Transplantation - pathology
Bone Transplantation - physiology
bovine deproteinized bone mineral
Cattle
Dentistry
early and late bone healing
Female
Forehead - surgery
Frontal Bone - pathology
Frontal Bone - surgery
Giant Cells - pathology
Goats
Image Processing, Computer-Assisted
Medical sciences
Minerals - therapeutic use
Osteogenesis - physiology
Otorhinolaryngology. Stomatology
platelet-rich plasma (PRP)
Platelet-Rich Plasma - physiology
Surgery
Time Factors
Wound Healing - physiology
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Summary:Abstract Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a mixture of autogenous bone and deproteinized bovine bone mineral (Bio-Oss® ) particles in goats. Four, round, critical size defects were made in the foreheads of 20 goats. In all goats the defects were filled with a mixture of autogenous particulate cancellous bone and (Bio-Oss® ) particles, in which 1 ml of PRP was added in two of the four defects. The goats were allocated to four subgroups each containing five goats, which were killed after 1, 2, 6 and 12 weeks. The results of the histological and histomorphometric examination showed that early and late bone healing were not enhanced when PRP was used.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2009.12.019