The Cholesterol Side-Chain Cleavage Complex in Human Brain White Matter

Specific antibodies obtained in rabbits after injection of bovine cholesterol side‐chain cleavage enzymes cytochrome P‐450scc, adrenodoxin and adrenodoxin‐reductase were used for immunohistochemical studies in human brain. The three enzymes were co‐localized in the white matter of the cerebellum. Th...

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Bibliographic Details
Published in:Journal of neuroendocrinology 1989-06, Vol.1 (3), p.153-156
Main Authors: Le Goascogne, C., Gouézou, M., Robel, P., Defaye, G., Chambaz, E., Waterman, M. R., Baulieu, E. E.
Format: Article
Language:English
Subjects:
adrenodoxin
adrenodoxin-reductase
cytochrome P-450scc
human cerebellum
immunohistochemistry
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Summary:Specific antibodies obtained in rabbits after injection of bovine cholesterol side‐chain cleavage enzymes cytochrome P‐450scc, adrenodoxin and adrenodoxin‐reductase were used for immunohistochemical studies in human brain. The three enzymes were co‐localized in the white matter of the cerebellum. This observation strongly suggests the existence of steroidogenic activity in human oligodendrocytes, as previously reported in the rat, and suggests that the concept of ‘neurosteroids’ can be applied to Δ5–3ß‐hydroxysteroid metabolites of cholesterol that accumulate in human brain.
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.1989.tb00095.x