Acute Action of Oestrogen on Medial Preoptic Gamma-Aminobutyric Acid Neurons: Correlation with Oestrogen Negative Feedback on Luteinizing Hormone Secretion

The acute effects of oestrogen on the medial preoptic area (MPOA) γ‐aminobutyric acid (GABA) system were examined by delivering an intravenous bolus of 17β‐oestradiol (5 μg/100 g body wt) to conscious ovariectomized rats implanted with microdialysis probes. Fifteen‐min blood samples were taken to de...

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Bibliographic Details
Published in:Journal of neuroendocrinology 1991-02, Vol.3 (1), p.101-106
Main Authors: Herbison, Allan E., Heavens, Robert P., Dye, Sandra, Dyer, Richard G.
Format: Article
Language:English
Subjects:
luteinizing hormone
microdialysis
oestradiol
rat
β-aminobutyric acid
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Summary:The acute effects of oestrogen on the medial preoptic area (MPOA) γ‐aminobutyric acid (GABA) system were examined by delivering an intravenous bolus of 17β‐oestradiol (5 μg/100 g body wt) to conscious ovariectomized rats implanted with microdialysis probes. Fifteen‐min blood samples were taken to determine the time‐course of negative feedback effects of oestrogen on luteinizing hormone (LH) secretion. Two h after administration of 17β‐oestradiol, GABA release from the MPOA was significantly elevated compared with vehicle‐treated controls (P
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.1991.tb00246.x