Time course of rocuronium-induced neuromuscular block after pre-treatment with magnesium sulphate: a randomised study

Background: A previously published study suggested that pre‐treatment with magnesium sulphate (MgSO4) had no impact on the speed of onset of rocuronium‐induced neuromuscular block. We set out to verify this assumption. Methods: Eighty patients (18–60 years) were randomly allocated to MgSO4 60 mg/kg...

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Published in:Acta anaesthesiologica Scandinavica 2010-03, Vol.54 (3), p.299-306
Main Authors: CZARNETZKI, C., LYSAKOWSKI, C., ELIA, N., TRAMÈR, M. R.
Format: Article
Language:English
Subjects:
Adjuvants, Anesthesia - adverse effects
Adolescent
Adult
Androstanols - adverse effects
Anesthesia
Anesthesia Recovery Period
Anesthesia, General
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Data Interpretation, Statistical
Electric Stimulation
Endpoint Determination
Female
Humans
Injections, Intravenous
Magnesium Sulfate - adverse effects
Male
Medical sciences
Middle Aged
Myography
Neuromuscular Blockade - adverse effects
Neuromuscular Nondepolarizing Agents - adverse effects
Premedication
Time Factors
Young Adult
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Summary:Background: A previously published study suggested that pre‐treatment with magnesium sulphate (MgSO4) had no impact on the speed of onset of rocuronium‐induced neuromuscular block. We set out to verify this assumption. Methods: Eighty patients (18–60 years) were randomly allocated to MgSO4 60 mg/kg or placebo (saline). Study drugs were given intravenously for 15 min before induction of anaesthesia with propofol, sufentanil and rocuronium 0.6 mg/kg. Anaesthesia was maintained with a target‐controlled propofol infusion. Neuromuscular transmission was measured using train‐of‐four (TOF)‐Watch SX® acceleromyography. Results: Onset was analysed in 37 MgSO4 and 38 saline patients, and recovery in 35 MgSO4 and 37 saline patients. Onset time (to 95% depression of T1) was on average 77 [SD=18] s with MgSO4 and 120 [48] s with saline (P
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.2009.02160.x