Plasma levels and urinary excretion of amino acids by subjects with renal calculi

Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with ma...

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Bibliographic Details
Published in:Amino acids 2010-05, Vol.38 (5), p.1277-1282
Main Authors: Atanassova, Stoyanka Slavcheva, Panchev, P, Ivanova, M
Format: Article
Language:English
Subjects:
Adult
Amino acids
Amino Acids - blood
Amino Acids - metabolism
Amino Acids - urine
Analytical Chemistry
Apatites - metabolism
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Calcium
Calcium Oxalate - metabolism
Calculi
Chromatography, High Pressure Liquid
Excretion
Female
Humans
Kidney Calculi - blood
Kidney Calculi - metabolism
Kidney Calculi - urine
Kidney stones
Life Sciences
Magnesium Compounds - metabolism
Male
Middle Aged
Neurobiology
Oxalates
Phosphates - metabolism
Plasma levels
Proteomics
renal calculi
Review Article
Stone
Struvite
Uric acid
Uric Acid - metabolism
Urine
Urine excretion
Urolithiasis
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Summary:Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium phosphate stones, either pure or mixed with apatite. Some types of stones (namely oxalate and uric acid calculi) are mainly formed as a result of a metabolic deficiency that may affect the amino acid metabolism, and thus may be reflected in the urinary amino acid pattern. Data demonstrated clearly that there is a general tendency towards decreased amino acid excretions in all SFs with all types of stones. As a whole, one can observe a higher percentage of patients with calcium oxalate and phosphate calculosis, who have low urine excretions of amino acids; about 50% are the SFs with lower urine excretion of serine, glycine, taurine and i-leucine; the high percentage of patients with CaOX calculi shows lower urine excretions of tyrosine and ornithine.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-009-0359-z