Long‐term results of disodium etidronate treatment in pulmonary alveolar microlithiasis

Pulmonary alveolar microlithiasis (PAM) is a rare disease with alveolar microliths mainly composed of calcium phosphate. The gene responsible for the disease is SLC34A2, which encodes a type‐IIb sodium phosphate cotransporter, has been described recently. Treatment of this disease is not clearly def...

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Published in:Pediatric pulmonology 2010-05, Vol.45 (5), p.514-517
Main Authors: Ozcelik, Ugur, Yalcin, Ebru, Arıyurek, Macit, Ersoz, Deniz Dogru, Cinel, Guzin, Gulhan, Bora, Kiper, Nural
Format: Article
Language:English
Subjects:
Calcium Phosphates - analysis
Child
Child, Preschool
Diphosphonates - therapeutic use
disodium etidronate
Etidronic Acid - therapeutic use
Female
Humans
Lithiasis - diagnostic imaging
Lithiasis - drug therapy
Lithiasis - genetics
Lung Diseases - diagnostic imaging
Lung Diseases - drug therapy
Lung Diseases - genetics
pulmonary alveolar microlithiasis
Pulmonary Alveoli
pulmonary microliths
Radiography
Sodium-Phosphate Cotransporter Proteins, Type IIb - genetics
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Summary:Pulmonary alveolar microlithiasis (PAM) is a rare disease with alveolar microliths mainly composed of calcium phosphate. The gene responsible for the disease is SLC34A2, which encodes a type‐IIb sodium phosphate cotransporter, has been described recently. Treatment of this disease is not clearly defined. Disodium etidronate is a member of bisphonates and it has been administered in these patients due to its inhibitory effect on the precipitation of hydroxyapatite microcrystals. Here, clinical and radiological improvement of two patients with PAM who were treated with disodium etidronate for 9 and 11 years, respectively, are presented. The pathogenetic mechanism of this treatment on the genetic basis of disease is discussed. Pediatr Pulmonol. 2010; 45:514–517. © 2010 Wiley‐Liss, Inc.
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.21209