Dokhwaljihwang-tang inhibits LPS-induced inflammatory cytokine production in peripheral blood mononuclear cells

Objectives: Dokhwaljihwang-tang, one of the prescriptions in Four Constitution medicine, has been used to treat neurological disorders. This work was aimed to examine the effect of Dokhwaljihwang-tang on lipopolysaccharide-induced inflammatory cytokine production in peripheral blood mononuclear cell...

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Bibliographic Details
Published in:Neurological research (New York) 2010-02, Vol.32 (sup1), p.48-52
Main Authors: Moon, Phil-Dong, Han, Na-Ra, Ko, Seong-Gum, Jeong, Hyun-Ja, Kim, Su-Jin, Lee, Bo-Ra, Kim, Na-Hyung, Choi, In-Young, An, Hyo-Jin, Myung, Noh-Yil, Lee, Hyejung, Kim, Myong-Jo, Kim, Ju-Sung, Hong, Seung-Heon, Kim, Hyung-Min, Um, Jae-Young
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Blotting, Western
Cytokines - metabolism
DOKHWALJIHWANG-TANG
Dose-Response Relationship, Drug
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - pharmacology
Enzyme-Linked Immunosorbent Assay
FOUR CONSTITUTION MEDICINE
Humans
INFLAMMATORY CYTOKINE
INFLAMMATORY DISEASES
Interleukin-1beta - metabolism
Interleukin-4 - metabolism
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Lipopolysaccharides - toxicity
Medicine, Korean Traditional
NF-kappa B - metabolism
NUCLEAR FACTOR KAPPA B
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Tumor Necrosis Factor-alpha - metabolism
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Summary:Objectives: Dokhwaljihwang-tang, one of the prescriptions in Four Constitution medicine, has been used to treat neurological disorders. This work was aimed to examine the effect of Dokhwaljihwang-tang on lipopolysaccharide-induced inflammatory cytokine production in peripheral blood mononuclear cells from the lesser yang subjects. Methods: The inflammatory cytokines, interleukin 1 beta, interleukin 4 and tumor necrosis factor were measured using the ELISA. The interleukin 1 beta mRNA expression was evaluated with reverse transcriptase-polymerase chain reaction. The expression level of nuclear factor kappa B was examined by western blotting. Results: Dokhwaljihwang-tang significantly inhibited interleukin 1 beta and interleukin 4 production (p
ISSN:0161-6412
1743-1328
DOI:10.1179/016164109X12537002793968