Determinants of C-reactive protein in individuals with very low socioeconomic status

Low socioeconomic (SE) status has been associated to inflammation and predictors of C-reactive protein (CRP) have been investigated by studies performed in developed countries. This study aimed to identify predictors of CRP in individuals of very low SE level in a developing country and evaluate whe...

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Published in:Arquivos brasileiros de cardiologia 2010-02, Vol.94 (2), p.202-223
Main Authors: Correia, Luis C L, Penalva, Rafaela, Correia, Helena, Ladeia, Ana M, Menezes, Marta, Suzart, Isaac, Moreira, Agnaluce, Lima, José Carlos, Galvão, Bernardo, Guimarães, Armênio C
Format: Article
Language:English
Subjects:
Acute Disease
Biomarkers - blood
Body Mass Index
Brazil
C-Reactive Protein - analysis
Developed Countries
Developing Countries
Female
Humans
Infection - epidemiology
Male
Middle Aged
Multivariate Analysis
Poverty
Predictive Value of Tests
Smoking - epidemiology
Social Class
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container_title Arquivos brasileiros de cardiologia
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creator Correia, Luis C L
Penalva, Rafaela
Correia, Helena
Ladeia, Ana M
Menezes, Marta
Suzart, Isaac
Moreira, Agnaluce
Lima, José Carlos
Galvão, Bernardo
Guimarães, Armênio C
description Low socioeconomic (SE) status has been associated to inflammation and predictors of C-reactive protein (CRP) have been investigated by studies performed in developed countries. This study aimed to identify predictors of CRP in individuals of very low SE level in a developing country and evaluate whether CRP is related to SE status in this scenario. Eight-two individuals of very low SE level were recruited from a poor, semi-rural community in Brazil. Thirty-two individuals of high socioeconomic level comprised a comparison sample. High-sensitivity CRP was measured by nephelometry. Eight-two individuals of very low SE level were recruited from a poor, semi-rural community in Brazil. Thirty-two individuals of high socioeconomic level comprised a comparison sample. High-sensitivity CRP was measured by nephelometry. In the low SE individuals, independent predictors of CRP were body mass index > 25 Kg/m(2) (P
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This study aimed to identify predictors of CRP in individuals of very low SE level in a developing country and evaluate whether CRP is related to SE status in this scenario. Eight-two individuals of very low SE level were recruited from a poor, semi-rural community in Brazil. Thirty-two individuals of high socioeconomic level comprised a comparison sample. High-sensitivity CRP was measured by nephelometry. Eight-two individuals of very low SE level were recruited from a poor, semi-rural community in Brazil. Thirty-two individuals of high socioeconomic level comprised a comparison sample. High-sensitivity CRP was measured by nephelometry. In the low SE individuals, independent predictors of CRP were body mass index &gt; 25 Kg/m(2) (P&lt;0.001), smoking (P=0.005) and acute infection conditions (P=0.049). The low SE group (median=2.02 mg/l; interquartile range 0.92 - 4.95 mg/dl) had higher CRP levels compared to the high SE group (1.16 mg/l, interquartile range 0.55 - 2.50 mg/dl, P=0.03). Body mass index tended to be higher (27 +/- 4.9 kg/m(2) vs 25.5 +/- 3.2 kg/m(2); P=0.07) and the prevalence of acute infection greater (32% vs 3%, P=0.002) in the low SE group. After overweight individuals and those with infectious conditions were excluded, the CRP levels were similar between the groups with low and high SE levels (0.93 mg/l vs 1.08 mg/l, P=0.28). Adiposity, infection conditions and smoking are predictors of CRP in individuals with very low SE level. 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The low SE group (median=2.02 mg/l; interquartile range 0.92 - 4.95 mg/dl) had higher CRP levels compared to the high SE group (1.16 mg/l, interquartile range 0.55 - 2.50 mg/dl, P=0.03). Body mass index tended to be higher (27 +/- 4.9 kg/m(2) vs 25.5 +/- 3.2 kg/m(2); P=0.07) and the prevalence of acute infection greater (32% vs 3%, P=0.002) in the low SE group. After overweight individuals and those with infectious conditions were excluded, the CRP levels were similar between the groups with low and high SE levels (0.93 mg/l vs 1.08 mg/l, P=0.28). Adiposity, infection conditions and smoking are predictors of CRP in individuals with very low SE level. 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source SciELO Brazil
subjects Acute Disease
Biomarkers - blood
Body Mass Index
Brazil
C-Reactive Protein - analysis
Developed Countries
Developing Countries
Female
Humans
Infection - epidemiology
Male
Middle Aged
Multivariate Analysis
Poverty
Predictive Value of Tests
Smoking - epidemiology
Social Class
title Determinants of C-reactive protein in individuals with very low socioeconomic status
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