Assessing the efficiency of a pharmacokinetic-based algorithm for target-controlled infusion of ketamine in ponies

The objective of this study was to assess a pharmacokinetic algorithm to predict ketamine plasma concentration and drive a target-controlled infusion (TCI) in ponies. Firstly, the algorithm was used to simulate the course of ketamine enantiomers plasma concentrations after the administration of an i...

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Bibliographic Details
Published in:Research in veterinary science 2010-06, Vol.88 (3), p.512-518
Main Authors: Levionnois, O.L., Mevissen, M., Thormann, W., Spadavecchia, C.
Format: Article
Language:English
Subjects:
Algorithms
Anesthetics, Dissociative - administration & dosage
Anesthetics, Dissociative - blood
Anesthetics, Dissociative - pharmacokinetics
Anesthetics, Dissociative - pharmacology
Animals
Biological Transport
blood plasma
Blood Pressure - drug effects
Body Temperature - drug effects
Drug dosages
drug evaluation
Drug therapy
Efficiency
Equine
Heart Rate
horses
Horses - metabolism
Infusions, Intravenous
Injections
intravenous injection
Ketamine
Ketamine - administration & dosage
Ketamine - blood
Ketamine - pharmacokinetics
Ketamine - pharmacology
Kinetics
Models, Biological
Pharmacokinetic algorithm
pharmacokinetics
Plasma
prediction
Predictive efficacy
Software
Target-controlled infusion
Veterinary medicine
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Summary:The objective of this study was to assess a pharmacokinetic algorithm to predict ketamine plasma concentration and drive a target-controlled infusion (TCI) in ponies. Firstly, the algorithm was used to simulate the course of ketamine enantiomers plasma concentrations after the administration of an intravenous bolus in six ponies based on individual pharmacokinetic parameters obtained from a previous experiment. Using the same pharmacokinetic parameters, a TCI of S-ketamine was then performed over 120 min to maintain a concentration of 1 μg/mL in plasma. The actual plasma concentrations of S-ketamine were measured from arterial samples using capillary electrophoresis. The performance of the simulation for the administration of a single bolus was very good. During the TCI, the S-ketamine plasma concentrations were maintained within the limit of acceptance (wobble and divergence
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2009.12.004