Alpha Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain Permeability in Rats with Subarachnoid Hemorrhage

The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH groups, which were ac...

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Bibliographic Details
Published in:Neurochemical research 2010-03, Vol.35 (3), p.418-428
Main Authors: Erşahin, Mehmet, Toklu, Hale Z., Çetinel, Şule, Yüksel, Meral, Erzik, Can, Berkman, M. Zafer, Yeğen, Berrak Ç., Şener, Göksel
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Basilar Artery - physiology
Behavior, Animal - drug effects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - pathology
Brain Edema - pathology
Brain Edema - prevention & control
Cell Biology
DNA Fragmentation
Evans Blue
Glutathione - metabolism
Luminescence
Male
Malondialdehyde - metabolism
Neurochemistry
Neurology
Neuroprotective Agents - pharmacology
Neurosciences
Original Paper
Oxidative Stress - drug effects
Permeability - drug effects
Peroxidase - metabolism
Rats
Rats, Wistar
Subarachnoid Hemorrhage - metabolism
Subarachnoid Hemorrhage - pathology
Thioctic Acid - pharmacology
Vasospasm, Intracranial - metabolism
Vasospasm, Intracranial - pathology
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Summary:The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH groups, which were accompanied with significant increases in the formation of reactive oxygen species, DNA fragmentation ratios, malondialdehyde levels and myeloperoxidase activity, while significant decreases in the brain glutathione content and Na + , K + -ATPase activity were observed. On the other hand, ALA treatment reversed all these biochemical indices as well as SAH-induced histopathological alterations. Increased brain edema, impaired blood-brain-barrier permeability and neurological scores were also improved by ALA treatment. The results demonstrate that ALA exerts neuroprotective effects via the enhancement of endogenous antioxidant enzyme activity, the inhibition of neutrophil accumulation and free radical generation, suggesting a therapeutic potential in reducing secondary injury after SAH in patients.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-009-0072-z