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Salivary‐Soluble CD44 Levels in Smokers and Non‐Smokers With Chronic Periodontitis: A Pilot Study

Background: Smoking is the most important environmental risk factor for periodontal disease. Elevated levels of serum‐soluble CD44 (sCD44) have been detected in smokers and also have been recognized as a diagnostic marker in some smoking‐induced diseases. The present study investigates the salivary...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2010-05, Vol.81 (5), p.710-717
Main Authors: Ghallab, Noha, Shaker, Olfat
Format: Article
Language:English
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Summary:Background: Smoking is the most important environmental risk factor for periodontal disease. Elevated levels of serum‐soluble CD44 (sCD44) have been detected in smokers and also have been recognized as a diagnostic marker in some smoking‐induced diseases. The present study investigates the salivary sCD44 profiles of smokers and non‐smokers with and without chronic periodontitis in response to scaling and root planing (SRP). Methods: The study included 44 subjects divided into two groups: 22 patients with chronic periodontitis and 22 periodontally healthy subjects. Both groups were equally subdivided into smokers (n = 11) and non‐smokers (n = 11). Plaque index, gingival index, probing depth, and clinical attachment level were recorded only for chronic periodontitis patients. Salivary samples were collected from all 44 patients at baseline and after 1 month of SRP from the 22 chronic periodontitis patients. Assay for salivary sCD44 was carried out by enzyme‐linked immunosorbent assay. Results: Baseline salivary sCD44 profiles were significantly higher when smokers were compared to non‐smokers in both chronic periodontitis patients and the control subjects (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2010.090630