Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia

In regulation of the developmental process, the balance between cellular proliferation and cell death is critical. Placental development tightly controls this mechanism, and increased apoptosis of placental trophoblasts can cause a variety of gynecological diseases. Members of the immortalization‐up...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2010-05, Vol.110 (2), p.522-530
Main Authors: Jeon, Su Yeon, Lee, Hyun-Jung, Park, Ji Myeong, Jung, Hyun Min, Yoo, Jung Ki, Lee, Hey-Jin, Lee, Jong-Sung, CHA, Dong-Hyun, Kim, Jin Kyeoung, Kim, Gi Jin
Format: Article
Language:English
Subjects:
apoptosis
Apoptosis - physiology
Base Sequence
Blotting, Western
Case-Control Studies
Cell Line, Transformed
DNA Primers
Female
Humans
hypoxia
Hypoxia - metabolism
Hypoxia - pathology
immortalization-upregulated proteins
In Situ Hybridization
Nuclear Proteins - physiology
pre-eclampsia
Pre-Eclampsia - metabolism
Pre-Eclampsia - pathology
Pregnancy
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factors - physiology
trophoblast
Trophoblasts - metabolism
Trophoblasts - pathology
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Summary:In regulation of the developmental process, the balance between cellular proliferation and cell death is critical. Placental development tightly controls this mechanism, and increased apoptosis of placental trophoblasts can cause a variety of gynecological diseases. Members of the immortalization‐upregulated protein (IMUP) family are nuclear proteins implicated in SV40‐mediated immortalization and cellular proliferation; however, the mechanisms by which their expression is regulated in placental development are still unknown. We compared IMUP‐2 expression in normal and pre‐eclamptic placental tissues and evaluated the function of IMUP‐2 in HTR‐8/SVneo trophoblast cells under hypoxic conditions. IMUP‐2 was expressed in syncytiotrophoblasts and syncytial knots of the placental villi. IMUP‐2 expression was significantly higher in preterm pre‐eclampsia patients than in patients who went to term (P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.22568