Diagnostic Value of Adenosine Deaminase Activity in Benign and Malignant Breast Tumors

Background and Aims The present study was carried out to evaluate the activity of adenosine deaminase (ADA) and its isoenzymes ADA1 and ADA2 activities as a diagnostic tool in patients with benign and malignant breast disease. Methods Total ADA, ADA1, and ADA2 activities of serum and tumor were anal...

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Bibliographic Details
Published in:Archives of medical research 2010, Vol.41 (1), p.14-18
Main Authors: Aghaei, Mahmoud, Karami-Tehrani, Fatemeh, Salami, Siamak, Atri, Morteza
Format: Article
Language:English
Subjects:
Adenosine deaminase
Adenosine Deaminase - blood
Adenosine Deaminase - metabolism
Adult
Aged
Benign breast disease
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - enzymology
Breast Neoplasms - pathology
Case-Control Studies
Female
Humans
Internal Medicine
Isoenzyme
Middle Aged
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Summary:Background and Aims The present study was carried out to evaluate the activity of adenosine deaminase (ADA) and its isoenzymes ADA1 and ADA2 activities as a diagnostic tool in patients with benign and malignant breast disease. Methods Total ADA, ADA1, and ADA2 activities of serum and tumor were analyzed using 58 subjects including 20 patients with benign breast disease (BBD), 34 patients with primary breast cancer, and 20 patients as normal control subjects. Results The mean values for total ADA and ADA2 activities in the serum and tumor of BBD were significantly higher than those of healthy controls ( p
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2009.10.012