One-Pot, Pd-Catalyzed Synthesis of trans-Dihydrobenzofurans from o-Aminophenols

An efficient and facile synthesis of trans-dihydrobenzofurans has been accomplished from o-aminophenols and phenylpropenes via a novel (one-pot) diastereoselective Pd-catalyzed oxyarylation reaction. The development and optimization of this method is described.

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Bibliographic Details
Published in:Organic letters 2010-05, Vol.12 (9), p.1976-1979
Main Authors: Coy B., Ericsson D., Jovanovic, Ljubisa, Sefkow, Michael
Format: Article
Language:English
Subjects:
Aminophenols - chemistry
Benzofurans - chemistry
Catalysis
Palladium - chemistry
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Description
Summary:An efficient and facile synthesis of trans-dihydrobenzofurans has been accomplished from o-aminophenols and phenylpropenes via a novel (one-pot) diastereoselective Pd-catalyzed oxyarylation reaction. The development and optimization of this method is described.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100433z