Preemptive Therapy in Adult Liver Transplant Recipients in CMV-Endemic Area

• Published in: Transplantation proceedings 2010-04, Vol.42 (3), p.825-829
• Main Authors: Kim, J.M, Kim, S.J, Joh, J.-W, Shin, M, Kim, E.Y, Moon, J.I, Jung, G.O, Choi, G.-S, Kwon, C.H.D, Lee, S.-K
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Cadaver; Cyclosporine - therapeutic use; Cytomegalovirus - isolation & purification; Cytomegalovirus Infections - epidemiology; Cytomegalovirus Infections - mortality; Cytomegalovirus Infections - prevention & control; Cytomegalovirus Infections - transmission; Endemic Diseases - prevention & control; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Rejection - immunology; Graft Rejection - prevention & control; Hepatitis B - epidemiology; Hepatitis C - epidemiology; Humans; Immunosuppressive Agents - therapeutic use; Korea; Liver Transplantation - adverse effects; Liver Transplantation - immunology; Living Donors - statistics & numerical data; Male; Medical sciences; Middle Aged; Mycophenolic Acid - analogs & derivatives; Mycophenolic Acid - therapeutic use; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tacrolimus - therapeutic use; Tissue Donors - statistics & numerical data; Tissue, organ and graft immunology
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.02.026

Abstract Cytomegalovirus (CMV) infection is not only a common complication after liver transplantation but also a significant contributing factor to morbidity and mortality. We investigated whether preemptive therapy can prevent CMV syndrome or tissue-invasive CMV disease in an endemic area. Preemptive therapy was initiated when more than 10 positive CMV pp65 antigen–positive cells per 400,000 white blood cells were detected, regardless of clinical manifestations. Intravenous ganciclovir as preemptive therapy was administered daily for 10 to 14 days until negative results were achieved. The incidence of initial CMV antigenemia and CMV syndrome during the posttransplantation period was 49.7% (353/710) and 5.2% (37/710), respectively. One hundred eight-two patients (51.6%) received ganciclovir as preemptive therapy. Patients with CMV antigenemia who received preemptive therapy had high Model for End-Stage Liver Disease score, repeat operation, renal dysfunction, infection, low hemoglobin concentration, low platelet count, low albumin concentration, high international normalized ratio, high total bilirubin value, high aspartate transaminase concentration, and high CMV peak titer. Cytomegalovirus syndrome and tissue-invasive CMV disease were more common in these patients. The survival curve in patients without CMV syndrome was better than that in those with CMV syndrome ( P = .000). Patients with more than 10 pp65 antigen–positive cells per 400,000 white blood cells should be treated aggressively with an antiviral agent as preemptive therapy because CMV infection is common in CMV-endemic areas and patients with CMV syndrome demonstrate poor survival rates.