Thyroid function 48h after delivery as a marker for subsequent postpartum depression

Physiological changes during gestation and after delivery are associated with postpartum thyroid dysfunction, which is due to thyroid autoimmunity in some cases. Postpartum thyroid dysfunction, in turn, has been associated with postpartum depression (PPD). The aim of the present study was to evaluat...

Full description

Saved in:
Bibliographic Details
Published in:Psychoneuroendocrinology 2010-06, Vol.35 (5), p.738-742
Main Authors: Albacar, Glòria, Sans, Teresa, Martín-Santos, Rocío, García-Esteve, Lluïsa, Guillamat, Roser, Sanjuan, Julio, Cañellas, Francesca, Carot, José Miguel, Gratacòs, Mònica, Bosch, Joan, Gaviria, Ana, Labad, Antonio, Zotes, Alfonso Gutiérrez, Vilella, Elisabet
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Biomarkers - blood
Depression, Postpartum - blood
Female
Humans
Postpartum Period - blood
Predictive Value of Tests
Thyrotropin - blood
Thyroxine - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Physiological changes during gestation and after delivery are associated with postpartum thyroid dysfunction, which is due to thyroid autoimmunity in some cases. Postpartum thyroid dysfunction, in turn, has been associated with postpartum depression (PPD). The aim of the present study was to evaluate whether thyroid function immediately after delivery can predict postpartum depression at 8 weeks and 32 weeks after delivery. This study examined 1053 postpartum Spanish women without a previous history of depression. We evaluated depressive symptoms at 48h, 8 weeks and 32 weeks postpartum and used a diagnostic interview to confirm major depression for all probable cases. Free thyroxin (fT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb) and C-reactive protein (CRP) were assayed at 48h postpartum. Binary and multivariate logistic regression analyses were performed to determine independent risk factors for PPD. Although 152 women (14.4%) had high TPOAb (>27IU/mL) and slightly elevated TSH concentrations with normal fT4, we did not find any association between thyroid function and PPD. This thyroid dysfunction was not associated with CRP concentrations that were outside of the normal range (>3mg/L). We conclude that thyroid function at 48h after delivery does not predict PPD susceptibility.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2009.10.015