Loading…

Controlled release of chlorhexidine from amorphous microporous silica

A new system for the controlled release of the antiseptic chlorhexidine is presented. Amorphous microporous silica (AMS) excipient material was synthesized via an acid catalyzed sol-gel method and shaped as powder or coating. Chlorhexidine diacetate was introduced into the pores of the AMS silica vi...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of controlled release 2010-02, Vol.142 (1), p.47-52
Main Authors:	VERRAEDT, E, PENDELA, M, ADAMS, E, HOOGMARTENS, J, MARTENS, J. A
Format:	Article
Language:	English
Subjects:	Anti-Infective Agents, Local - administration & dosage Antiseptics Biological and medical sciences Chlorhexidine Chlorhexidine - administration & dosage Coatings Controlled release Delayed-Action Preparations - chemistry Diffusion General pharmacology Medical sciences Particle size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pores Porosity Powder Silica Silicon Silicon Dioxide - chemistry
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c437t-27907c890f59f3b1883c72f0b91feb4f3e6ab901a162ef7f0f81a1866b8681793
cites	cdi_FETCH-LOGICAL-c437t-27907c890f59f3b1883c72f0b91feb4f3e6ab901a162ef7f0f81a1866b8681793
container_end_page	52
container_issue	1
container_start_page	47
container_title	Journal of controlled release
container_volume	142
creator	VERRAEDT, E PENDELA, M ADAMS, E HOOGMARTENS, J MARTENS, J. A
description	A new system for the controlled release of the antiseptic chlorhexidine is presented. Amorphous microporous silica (AMS) excipient material was synthesized via an acid catalyzed sol-gel method and shaped as powder or coating. Chlorhexidine diacetate was introduced into the pores of the AMS silica via the incipient wetness impregnation method. This silica reservoir maintained a slow release of chlorhexidine over more than 7days. Chlorhexidine release was controlled by configurational diffusion in the AMS pores having free diameters of less than 1nm. The release of chlorhexidine was fine tuned by adapting particle size and pore diameter. Controlled release of chlorhexidine from an AMS coating on silicon wafer was demonstrated.
doi_str_mv	10.1016/j.jconrel.2009.09.022
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733942010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733942010</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-27907c890f59f3b1883c72f0b91feb4f3e6ab901a162ef7f0f81a1866b8681793</originalsourceid><addsrcrecordid>eNp9kctKxDAUhoMozjj6CEo3opvWk6TNZSnDeIEBN7ouaSZhWtJmTGZA396UKboTfjhn8Z3bfxC6xlBgwOyhKzrth2BcQQBkMYqQEzTHgtO8lLI6RfPEiZyySs7QRYwdAFS05OdohqWAMmmOVks_7IN3zmyy1MyoaDJvM711PmzNV7tpB5PZ4PtM9T7stv4Qs77Vwe98GPPYularS3RmlYvmaooL9PG0el--5Ou359fl4zrXJeX7nHAJXAsJtpKWNlgIqjmx0EhsTVNaaphqJGCFGTGWW7Ai5YKxRjCBuaQLdHfsuwv-82Divu7bqI1zajBpm5pTKksCGBJ5_y-ZPCwxMClYQqsjmq6KMRhb70Lbq_CdoJFjdVdPXtej1_UoQlLdzTTi0PRm81c1mZuA2wlQUStngxp0G385QsY3lUB_ANvOiZM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1014106986</pqid></control><display><type>article</type><title>Controlled release of chlorhexidine from amorphous microporous silica</title><source>Elsevier</source><creator>VERRAEDT, E ; PENDELA, M ; ADAMS, E ; HOOGMARTENS, J ; MARTENS, J. A</creator><creatorcontrib>VERRAEDT, E ; PENDELA, M ; ADAMS, E ; HOOGMARTENS, J ; MARTENS, J. A</creatorcontrib><description>A new system for the controlled release of the antiseptic chlorhexidine is presented. Amorphous microporous silica (AMS) excipient material was synthesized via an acid catalyzed sol-gel method and shaped as powder or coating. Chlorhexidine diacetate was introduced into the pores of the AMS silica via the incipient wetness impregnation method. This silica reservoir maintained a slow release of chlorhexidine over more than 7days. Chlorhexidine release was controlled by configurational diffusion in the AMS pores having free diameters of less than 1nm. The release of chlorhexidine was fine tuned by adapting particle size and pore diameter. Controlled release of chlorhexidine from an AMS coating on silicon wafer was demonstrated.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2009.09.022</identifier><identifier>PMID: 19804804</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Kidlington: Elsevier</publisher><subject>Anti-Infective Agents, Local - administration & dosage ; Antiseptics ; Biological and medical sciences ; Chlorhexidine ; Chlorhexidine - administration & dosage ; Coatings ; Controlled release ; Delayed-Action Preparations - chemistry ; Diffusion ; General pharmacology ; Medical sciences ; Particle size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Pores ; Porosity ; Powder ; Silica ; Silicon ; Silicon Dioxide - chemistry</subject><ispartof>Journal of controlled release, 2010-02, Vol.142 (1), p.47-52</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-27907c890f59f3b1883c72f0b91feb4f3e6ab901a162ef7f0f81a1866b8681793</citedby><cites>FETCH-LOGICAL-c437t-27907c890f59f3b1883c72f0b91feb4f3e6ab901a162ef7f0f81a1866b8681793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22499540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19804804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VERRAEDT, E</creatorcontrib><creatorcontrib>PENDELA, M</creatorcontrib><creatorcontrib>ADAMS, E</creatorcontrib><creatorcontrib>HOOGMARTENS, J</creatorcontrib><creatorcontrib>MARTENS, J. A</creatorcontrib><title>Controlled release of chlorhexidine from amorphous microporous silica</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>A new system for the controlled release of the antiseptic chlorhexidine is presented. Amorphous microporous silica (AMS) excipient material was synthesized via an acid catalyzed sol-gel method and shaped as powder or coating. Chlorhexidine diacetate was introduced into the pores of the AMS silica via the incipient wetness impregnation method. This silica reservoir maintained a slow release of chlorhexidine over more than 7days. Chlorhexidine release was controlled by configurational diffusion in the AMS pores having free diameters of less than 1nm. The release of chlorhexidine was fine tuned by adapting particle size and pore diameter. Controlled release of chlorhexidine from an AMS coating on silicon wafer was demonstrated.</description><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Antiseptics</subject><subject>Biological and medical sciences</subject><subject>Chlorhexidine</subject><subject>Chlorhexidine - administration & dosage</subject><subject>Coatings</subject><subject>Controlled release</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Diffusion</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Particle size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Pores</subject><subject>Porosity</subject><subject>Powder</subject><subject>Silica</subject><subject>Silicon</subject><subject>Silicon Dioxide - chemistry</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kctKxDAUhoMozjj6CEo3opvWk6TNZSnDeIEBN7ouaSZhWtJmTGZA396UKboTfjhn8Z3bfxC6xlBgwOyhKzrth2BcQQBkMYqQEzTHgtO8lLI6RfPEiZyySs7QRYwdAFS05OdohqWAMmmOVks_7IN3zmyy1MyoaDJvM711PmzNV7tpB5PZ4PtM9T7stv4Qs77Vwe98GPPYularS3RmlYvmaooL9PG0el--5Ou359fl4zrXJeX7nHAJXAsJtpKWNlgIqjmx0EhsTVNaaphqJGCFGTGWW7Ai5YKxRjCBuaQLdHfsuwv-82Divu7bqI1zajBpm5pTKksCGBJ5_y-ZPCwxMClYQqsjmq6KMRhb70Lbq_CdoJFjdVdPXtej1_UoQlLdzTTi0PRm81c1mZuA2wlQUStngxp0G385QsY3lUB_ANvOiZM</recordid><startdate>20100225</startdate><enddate>20100225</enddate><creator>VERRAEDT, E</creator><creator>PENDELA, M</creator><creator>ADAMS, E</creator><creator>HOOGMARTENS, J</creator><creator>MARTENS, J. A</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20100225</creationdate><title>Controlled release of chlorhexidine from amorphous microporous silica</title><author>VERRAEDT, E ; PENDELA, M ; ADAMS, E ; HOOGMARTENS, J ; MARTENS, J. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-27907c890f59f3b1883c72f0b91feb4f3e6ab901a162ef7f0f81a1866b8681793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Antiseptics</topic><topic>Biological and medical sciences</topic><topic>Chlorhexidine</topic><topic>Chlorhexidine - administration & dosage</topic><topic>Coatings</topic><topic>Controlled release</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Diffusion</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Particle size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Pores</topic><topic>Porosity</topic><topic>Powder</topic><topic>Silica</topic><topic>Silicon</topic><topic>Silicon Dioxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VERRAEDT, E</creatorcontrib><creatorcontrib>PENDELA, M</creatorcontrib><creatorcontrib>ADAMS, E</creatorcontrib><creatorcontrib>HOOGMARTENS, J</creatorcontrib><creatorcontrib>MARTENS, J. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VERRAEDT, E</au><au>PENDELA, M</au><au>ADAMS, E</au><au>HOOGMARTENS, J</au><au>MARTENS, J. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled release of chlorhexidine from amorphous microporous silica</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2010-02-25</date><risdate>2010</risdate><volume>142</volume><issue>1</issue><spage>47</spage><epage>52</epage><pages>47-52</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>A new system for the controlled release of the antiseptic chlorhexidine is presented. Amorphous microporous silica (AMS) excipient material was synthesized via an acid catalyzed sol-gel method and shaped as powder or coating. Chlorhexidine diacetate was introduced into the pores of the AMS silica via the incipient wetness impregnation method. This silica reservoir maintained a slow release of chlorhexidine over more than 7days. Chlorhexidine release was controlled by configurational diffusion in the AMS pores having free diameters of less than 1nm. The release of chlorhexidine was fine tuned by adapting particle size and pore diameter. Controlled release of chlorhexidine from an AMS coating on silicon wafer was demonstrated.</abstract><cop>Kidlington</cop><pub>Elsevier</pub><pmid>19804804</pmid><doi>10.1016/j.jconrel.2009.09.022</doi><tpages>6</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0168-3659
ispartof	Journal of controlled release, 2010-02, Vol.142 (1), p.47-52
issn	0168-3659 1873-4995
language	eng
recordid	cdi_proquest_miscellaneous_733942010
source	Elsevier
subjects	Anti-Infective Agents, Local - administration & dosage Antiseptics Biological and medical sciences Chlorhexidine Chlorhexidine - administration & dosage Coatings Controlled release Delayed-Action Preparations - chemistry Diffusion General pharmacology Medical sciences Particle size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pores Porosity Powder Silica Silicon Silicon Dioxide - chemistry
title	Controlled release of chlorhexidine from amorphous microporous silica
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T16%3A33%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Controlled%20release%20of%20chlorhexidine%20from%20amorphous%20microporous%20silica&rft.jtitle=Journal%20of%20controlled%20release&rft.au=VERRAEDT,%20E&rft.date=2010-02-25&rft.volume=142&rft.issue=1&rft.spage=47&rft.epage=52&rft.pages=47-52&rft.issn=0168-3659&rft.eissn=1873-4995&rft.coden=JCREEC&rft_id=info:doi/10.1016/j.jconrel.2009.09.022&rft_dat=%3Cproquest_cross%3E733942010%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c437t-27907c890f59f3b1883c72f0b91feb4f3e6ab901a162ef7f0f81a1866b8681793%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1014106986&rft_id=info:pmid/19804804&rfr_iscdi=true