Plasma visfatin levels in preeclamptic and normal pregnancies

Objective Increasing evidences support the participation of adipokines in the pathogenesis of preeclampsia (PE). Visfatin is a novel adipokine secreted by fat tissue and macrophages and is involved in the regulation of glucose homeostasis. Our aim is to investigate visfatin levels in women with PE,...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2010-06, Vol.281 (6), p.995-998
Main Authors: Zulfıkaroglu, Ebru, Isman, Ferruh, Payaslı, Ahmet, Kılıc, Sevtap, Kucur, Mıne, Danısman, Nurı
Format: Article
Language:English
Subjects:
Adult
Endocrinology
Female
Gynecology
Human Genetics
Humans
Materno-fetal Medicine
Medicine
Medicine & Public Health
Nicotinamide Phosphoribosyltransferase - blood
Obstetrics/Perinatology/Midwifery
Pre-Eclampsia - blood
Preeclampsia
Pregnancy - blood
Pregnancy Trimester, Third - blood
Young Adult
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Summary:Objective Increasing evidences support the participation of adipokines in the pathogenesis of preeclampsia (PE). Visfatin is a novel adipokine secreted by fat tissue and macrophages and is involved in the regulation of glucose homeostasis. Our aim is to investigate visfatin levels in women with PE, women with the third trimester of normal pregnancy and healthy non-pregnant women. Patients and methods We included 32 preeclamptic patients who received antenatal and obstetric care at Perinatology Clinic. A total of 32 pregnant women with normal ongoing pregnancies and 32 non-pregnant women were taken as the control groups. Plasma levels of visfatin were quantified by ELISA. Results Plasma levels of visfatin were 63.8 ± 4.9 ng/ml in women with PE, 43.6 ± 7.8 ng/ml in pregnant control and 31.6 ± 4.2 ng/ml in the non-pregnant control, respectively ( P  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-009-1192-z