Histopathologic improvement in biliary cirrhosis after definitive surgery for choledochal cyst

Abstract Choledochal cyst causes liver fibrosis, the extent of which varies with each case. Liver damage seldom progresses to cirrhosis, but when it does, it is generally irreversible. We report an infantile case of liver cirrhosis associated with choledochal cyst in which complete clinical resoluti...

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Bibliographic Details
Published in:Journal of pediatric surgery 2010-05, Vol.45 (5), p.e11-e14
Main Authors: Ishimaru, Tetsuya, Kitano, Yoshihiro, Uchida, Hiroo, Kawashima, Hiroshi, Gotoh, Chikashi, Satoh, Kaori, Yoshida, Mariko, Kishimoto, Hiroshi, Iwanaka, Tadashi
Format: Article
Language:English
Subjects:
Biliary cirrhosis
Choledochal cyst
Choledochal Cyst - complications
Choledochal Cyst - surgery
Female
Histopathology
Humans
Infant
Liver Cirrhosis, Biliary - etiology
Liver Cirrhosis, Biliary - pathology
Liver Cirrhosis, Biliary - surgery
Liver fibrosis, Infant
Pediatrics
Recovery of Function
Surgery
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Summary:Abstract Choledochal cyst causes liver fibrosis, the extent of which varies with each case. Liver damage seldom progresses to cirrhosis, but when it does, it is generally irreversible. We report an infantile case of liver cirrhosis associated with choledochal cyst in which complete clinical resolution was achieved by surgery. Pancytopenia caused by splenomegaly, massive ascites, hypoalbuminemia, and coagulation abnormality that were observed during the early postoperative period had disappeared within 4 months after surgery. Needle liver biopsy performed at 1 year after surgery revealed marked improvement in liver fibrosis.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2010.01.030