Anaplastic large cell Ki-1 lymphoma in the central nervous system : report of an autopsy case

A 45-year old immunocompetent man presented with multiple lesions in the brain. A histological examination of the tumors showed a diffuse infiltrate of lymphoid cells with cellular polymorphism and of multinucleated giant cells. These cells were immunolabeled with antibodies against B cell lineage a...

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Bibliographic Details
Published in:Acta neuropathologica 1992-10, Vol.84 (5), p.577-580
Main Authors: MIYAZONO, M, IWAKI, T, TATEISHI, J, FUKUI, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Humans
Lymphoma, Large B-Cell, Diffuse - diagnostic imaging
Lymphoma, Large B-Cell, Diffuse - immunology
Lymphoma, Large B-Cell, Diffuse - pathology
Male
Medical sciences
Middle Aged
Neurology
Tomography, X-Ray Computed
Tumors of the nervous system. Phacomatoses
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Summary:A 45-year old immunocompetent man presented with multiple lesions in the brain. A histological examination of the tumors showed a diffuse infiltrate of lymphoid cells with cellular polymorphism and of multinucleated giant cells. These cells were immunolabeled with antibodies against B cell lineage and with a monoclonal antibody, Ber-H2 (CD30), which showed the presence of Ki-1 antigen. Recently, among systemic non-Hodgkin's lymphomas, attention has been given to Ki-1-positive lymphomas, which have been incorporated in the up-dated Kiel classification. We report here a case of Ki-1-positive lymphoma arising in the CNS and review previously reported cases.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00304479