Gamiwalbitang, composed of four herbs, controls body weight increase and lipid level elevation induced by a high-fat diet in mice

• Published in: Immunopharmacology and immunotoxicology 2010-06, Vol.32 (2), p.307-312
• Main Authors: An, Hyo-Jin, Rim, Hong-Kun, Suh, Se-Eun, Jeong, Hyun-Ja, Um, Jae-Young, Hong, Seung-Heon, Kim, Hyung-Min
• Format: Article
• Language: English
• Subjects: Adipose Tissue - drug effects; Animals; Anti-Obesity Agents - administration & dosage; Anti-Obesity Agents - pharmacology; Anti-Obesity Agents - therapeutic use; body weight; Body Weight - drug effects; Dietary Fats - administration & dosage; Dietary Fats - adverse effects; Dietary Supplements; Enzyme-Linked Immunosorbent Assay; Epididymis - drug effects; Gamiwalbitang; high-density lipoprotein cholesterol; high-fat diet; Lipids - blood; low-density lipoprotein cholesterol; Male; Mice; Mice, Inbred C57BL; obesity; Obesity - blood; Obesity - prevention & control; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Preparations - administration & dosage; Plant Preparations - pharmacology; Plant Preparations - therapeutic use; triglyceride
• ISSN: 0892-3973; 1532-2513
• DOI: 10.3109/08923970903335108

Gamiwalbitang (GWB) is a newly developed dietary supplement that is composed of four herbs. The purpose of GWB development is to help control weight. The aim of this study was to investigate whether GWB combined with a 40% high-fat (HF) diet can influence body weight and fat accumulation. An experiment was conducted with 40 C57BL/6J mice with an initial body weight of approximately 18g. Body weight was recorded weekly, and plasma levels of triglyceride, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and leptin were analyzed at the end of the study. Weight increases in the 10% GWB group were 38.5% less than in the HF diet group (P