Acute cardiac effects of marathon running

We sought to clarify the significance of cardiac dysfunction and to assess its relationship with elevated biomarkers by using cardiovascular magnetic resonance imaging in healthy, middle-aged subjects immediately after they ran 26.2 miles. Cardiac dysfunction and elevated blood markers of myocardial...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2010-05, Vol.108 (5), p.1148-1153
Main Authors: TRIVAX, Justin E, FRANKLIN, Barry A, GOLDSTEIN, James A, CHINNAIYAN, Kavitha M, GALLAGHER, Michael J, DEJONG, Adam T, COLAR, James M, HAINES, David E, MCCULLOUGH, Peter A
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
Biological and medical sciences
Biomarkers
Biomarkers - blood
Cardiac arrhythmia
Cardiovascular system
Electrocardiography, Ambulatory
Exercise
Exercise Test
Female
Fundamental and applied biological sciences. Psychology
Heart
Heart Atria - pathology
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Magnetic Resonance Imaging
Male
Marathons
Middle Aged
Myocardium - metabolism
Myocardium - pathology
Natriuretic Peptide, Brain - blood
Oxygen Consumption
Physical Endurance
Running
Stroke Volume
Time Factors
Troponin I - blood
Ventricular Dysfunction, Right - etiology
Ventricular Dysfunction, Right - metabolism
Ventricular Dysfunction, Right - pathology
Ventricular Dysfunction, Right - physiopathology
Ventricular Function, Left
Ventricular Function, Right
Young Adult
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Summary:We sought to clarify the significance of cardiac dysfunction and to assess its relationship with elevated biomarkers by using cardiovascular magnetic resonance imaging in healthy, middle-aged subjects immediately after they ran 26.2 miles. Cardiac dysfunction and elevated blood markers of myocardial injury have been reported after prolonged strenuous exercise. From 425 volunteers, 13 women and 12 men were randomly selected, provided medical and training history, and underwent baseline cardiopulmonary exercise testing to exhaustion. Blood biomarkers, cardiovascular magnetic resonance imaging, and 24-h ambulatory electrocardiography were performed 4 wk before and immediately after the race. Participants were 38.7+/-9.0 yr old, had baseline peak oxygen consumption of 52.9+/-5.6 ml.kg(-1).min(-1), and completed the marathon in 256.2+/-43.5 min. Cardiac troponin I and B-type natriuretic peptide increased following the race (P=0.001 and P
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.01151.2009