Selective Aggregation of a Platinum-Gadolinium Complex Within a Tumor-Cell Nucleus

Hitching a ride: Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex results in the selective aggregation of the intact drug within the cell nuclei, as determined by synchrotron X‐ray fluorescence (XRF) imaging (see images). This work is the first example of gadoliniu...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2010-02, Vol.49 (7), p.1231-1233
Main Authors: Crossley, Ellen L, Aitken, Jade B, Vogt, Stefan, Harris, Hugh H, Rendina, Louis M
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
bioinorganic chemistry
Cell Line, Tumor
Cell Nucleus - metabolism
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - metabolism
DNA
Fluorescent Dyes - chemistry
gadolinium
Gadolinium - chemistry
Humans
Intercalating Agents - chemical synthesis
Intercalating Agents - metabolism
platinum
Platinum - chemistry
Spectrometry, X-Ray Emission
tumors
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Summary:Hitching a ride: Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex results in the selective aggregation of the intact drug within the cell nuclei, as determined by synchrotron X‐ray fluorescence (XRF) imaging (see images). This work is the first example of gadolinium delivery by a platinum complex to a tumor‐cell nucleus.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200902309