The steady-state phase distribution of the motor switch complex model of Halobacterium salinarum

Steady-state analysis is performed on the kinetic model for the switch complex of the flagellar motor of Halobacterium salinarum (Nutsch et al. [16]). The existence and uniqueness of a positive steady-state of the system is established and it is demonstrated why the steady-state is centered around t...

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Bibliographic Details
Published in:Mathematical biosciences 2009-12, Vol.222 (2), p.117-126
Main Authors: del Rosario, Ricardo C.H., Diener, Francine, Diener, Marc, Oesterhelt, Dieter
Format: Article
Language:English
Subjects:
87.17.Aa
87.17.Jj
Algorithms
Archaeal flagellar motor
Bacterial Proteins - physiology
Cell Movement - physiology
Computer Simulation
Flagella - physiology
Halobacterium salinarum
Halobacterium salinarum - physiology
Kinetics
Linear Models
Membrane Proteins - physiology
Methyl-Accepting Chemotaxis Proteins
Models, Biological
Molecular Motor Proteins - physiology
Nonlinear Dynamics
Phototaxis
Signal Transduction - physiology
Steady-state analysis
Systems Biology - methods
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Summary:Steady-state analysis is performed on the kinetic model for the switch complex of the flagellar motor of Halobacterium salinarum (Nutsch et al. [16]). The existence and uniqueness of a positive steady-state of the system is established and it is demonstrated why the steady-state is centered around the competent phase, a state of the motor in which it is able to respond to light stimuli. It is also demonstrated why the steady-state shifts to the refractory phase when the steady-state value of the response regulator CheYP increases. This work is one aspect of modeling in systems biology wherein the mathematical properties of a model are established.
ISSN:0025-5564
1879-3134
DOI:10.1016/j.mbs.2009.10.002