Tetranectin is a potential biomarker in cerebrospinal fluid and serum of patients with epilepsy

Tetranectin (TN) is a plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes via binding to plasminogen. A previous proteomics study identified TN in the cerebrospinal fluid (CSF) of epileptic patients but not in healthy controls. We determined the concentrations...

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Bibliographic Details
Published in:Clinica chimica acta 2010-04, Vol.411 (7), p.581-583
Main Authors: Wang, Liang, Pan, Yumin, Chen, Dan, Xiao, Zheng, Xi, Zhiqin, Xiao, Fei, Wang, Xuefeng
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Cerebrospinal fluid
Cerebrospinal Fluid - chemistry
Cerebrospinal Fluid - metabolism
Child
ELISA
Epilepsy
Epilepsy - blood
Epilepsy - cerebrospinal fluid
Epilepsy - diagnosis
Female
Humans
Lectins, C-Type - blood
Male
Middle Aged
Serum
Tetranectin
Young Adult
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Summary:Tetranectin (TN) is a plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes via binding to plasminogen. A previous proteomics study identified TN in the cerebrospinal fluid (CSF) of epileptic patients but not in healthy controls. We determined the concentrations of TN in CSF and serum of epileptic patients to evaluate the changes in TN levels after epileptic attack. We detected TN in the CSF and serum of 64 epileptic patients and 26 healthy subjects using sandwich enzyme-linked immunosorbent assays. Compared with the control group, CSF-TN levels increased in epileptic patients while serum-TN levels decreased. These differences were statistically significant. The decrease of serum-TN in patients with drug-refractory epilepsy was the most striking. CSF-TN and serum-TN are potential biomarkers in epilepsy and drug-refractory epilepsy and would be useful for diagnosis.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2010.01.022