Paraventricular Hypothalamic Clonidine Increases Rather Than Decreases Susceptibility to Activity-Based Anorexia in the Rat

Anorexia has been related to reduced activity of the paraventricular hypothalamic (PVN) noradrenergic-feeding system. In this study we determined whether clonidine (an α2-adrenergic agonist) infused into the PVN reduced susceptibility to activity-based anorexia (ABA) in the rat. In Experiment 1, clo...

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Bibliographic Details
Published in:Behavioral neuroscience 1992-12, Vol.106 (6), p.1015-1022
Main Authors: Rieg, Thomas S, Aravich, Paul F
Format: Article
Language:English
Subjects:
Activity Level
Adult and adolescent clinical studies
AGONISTS
ALPHA-ADRENERGIC RECEPTORS
Animal
Animal Models
Animals
Anorexia
Anorexia Nervosa
APETITO
APPETIT
APPETITE
Appetite - drug effects
Biological and medical sciences
Body Weight - drug effects
BRAIN
CEREBRO
Clonidine
Clonidine - pharmacology
DIGESTIVE DISORDERS
Dose-Response Relationship, Drug
Eating behavior disorders
ENCEPHALE
ESTIMULO
FOOD INTAKE
HORMONE RECEPTORS
Hunger - drug effects
HYPOTHALAMUS
INGESTION DE ALIMENTOS
Male
Medical research
Medical sciences
Motor Activity - drug effects
Paraventricular Hypothalamic Nucleus - drug effects
paraventricular noradrenergic feeding
PRISE ALIMENTAIRE
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
RAT
RATA
RATS
Rats, Sprague-Dawley
RECEPTEUR D'HORMONE
RECEPTORES DE HORMONAS
Receptors, Adrenergic - drug effects
Rodents
STIMULATION
STIMULI
STIMULUS
TRASTORNOS DIGESTIVOS
TROUBLE DIGESTIF
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Summary:Anorexia has been related to reduced activity of the paraventricular hypothalamic (PVN) noradrenergic-feeding system. In this study we determined whether clonidine (an α2-adrenergic agonist) infused into the PVN reduced susceptibility to activity-based anorexia (ABA) in the rat. In Experiment 1, clonidine (6 doses) was chronically infused into the PVN of male Sprague-Dawley rats. All animals were exposed to ABA (1.5 hr/day food access; 22.5 hr/day running wheel access) until a 25% body weight loss was reached. Dose-related increases in susceptibility to ABA and decreases in food intake were observed. In Experiment 2, for which heavier animals and 3 doses of clonidine were used, we found no difference in food intake and wheel activity but increased susceptibility to ABA. Chronic clonidine infused into the PVN does not produce hyperphagia and exacerbates rather than attenuates susceptibility to ABA.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.106.6.1015