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Direct Visualization of the Dendritic and Receptive Fields of Directionally Selective Retinal Ganglion Cells

Optical methods were used to locate the cell bodies of directionally selective ganglion cells in isolated rabbit retinas. These neurons detect the direction in which images move across the retinal surface and transmit that information to the brain. The receptive field of each identified cell was det...

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Published in:	Science (American Association for the Advancement of Science) 1992-12, Vol.258 (5090), p.1949-1952
Main Authors:	Yang, Guang, Masland, Richard H.
Format:	Article
Language:	English
Subjects:	Action potentials Amacrine cells Amidines Animals Biological and medical sciences Cell physiology Dendrites Dendrites - physiology Dendrites - ultrastructure Electrodes Eye and associated structures. Visual pathways and centers. Vision Eye Movements Fluorescent Dyes Fundamental and applied biological sciences. Psychology Ganglia Neurons Optic Nerve - physiology Photoreceptors Rabbits Retina Retinal Ganglion Cells - cytology Retinal Ganglion Cells - physiology Retinal images Vertebrates: nervous system and sense organs
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cited_by	cdi_FETCH-LOGICAL-c714t-c8b3d1e0f8094437334e744c988933751639bf321e07eb37ecb6d8ce5a9acfe53
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container_end_page	1952
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container_title	Science (American Association for the Advancement of Science)
container_volume	258
creator	Yang, Guang Masland, Richard H.
description	Optical methods were used to locate the cell bodies of directionally selective ganglion cells in isolated rabbit retinas. These neurons detect the direction in which images move across the retinal surface and transmit that information to the brain. The receptive field of each identified cell was determined, after which the cell was injected with Lucifer yellow. An image of the receptive field border was then projected onto the fluorescent image of the dendrites, allowing precise comparison between them. The size of the receptive field matched closely the size of the dendritic arbor of that cell. This result restricts the types of convergence that can be postulated in modeling the mechanism of retinal directional selectivity.
doi_str_mv	10.1126/science.1470920
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Psychology ; Ganglia ; Neurons ; Optic Nerve - physiology ; Photoreceptors ; Rabbits ; Retina ; Retinal Ganglion Cells - cytology ; Retinal Ganglion Cells - physiology ; Retinal images ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 1992-12, Vol.258 (5090), p.1949-1952</ispartof><rights>Copyright 1992 American Association for the Advancement of Science</rights><rights>1993 INIST-CNRS</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c714t-c8b3d1e0f8094437334e744c988933751639bf321e07eb37ecb6d8ce5a9acfe53</citedby><cites>FETCH-LOGICAL-c714t-c8b3d1e0f8094437334e744c988933751639bf321e07eb37ecb6d8ce5a9acfe53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2880479$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2880479$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,2870,2871,27903,27904,33591,33857,58216,58449</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4521987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1470920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Guang</creatorcontrib><creatorcontrib>Masland, Richard H.</creatorcontrib><title>Direct Visualization of the Dendritic and Receptive Fields of Directionally Selective Retinal Ganglion Cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Optical methods were used to locate the cell bodies of directionally selective ganglion cells in isolated rabbit retinas. These neurons detect the direction in which images move across the retinal surface and transmit that information to the brain. The receptive field of each identified cell was determined, after which the cell was injected with Lucifer yellow. An image of the receptive field border was then projected onto the fluorescent image of the dendrites, allowing precise comparison between them. The size of the receptive field matched closely the size of the dendritic arbor of that cell. This result restricts the types of convergence that can be postulated in modeling the mechanism of retinal directional selectivity.</description><subject>Action potentials</subject><subject>Amacrine cells</subject><subject>Amidines</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Dendrites</subject><subject>Dendrites - physiology</subject><subject>Dendrites - ultrastructure</subject><subject>Electrodes</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Eye Movements</subject><subject>Fluorescent Dyes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia</subject><subject>Neurons</subject><subject>Optic Nerve - physiology</subject><subject>Photoreceptors</subject><subject>Rabbits</subject><subject>Retina</subject><subject>Retinal Ganglion Cells - cytology</subject><subject>Retinal Ganglion Cells - physiology</subject><subject>Retinal images</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqN0s1v0zAUAHALgUYZnLmAlANCHJbNjp3EPo6OlUkVlTbYNXKcl-LJdTrbQYy_HkeJiipVovLBH-_3niy9h9Bbgs8JyYoLrzRYBeeElVhk-BmaESzyNB7pczTDmBYpx2X-Er3y_gHjGBP0BJ1MfIbMlXagQnKvfS-N_iOD7mzStUn4CckV2MbpoFUibZPcgoJt0L8gudZgGj-oMTumSGOekjswwy2KWwg6viULaddmqDgHY_xr9KKVxsObaT9FP66_fJ9_TZerxc38cpmqkrCQKl7ThgBuORaM0ZJSBiVjSnAuKC1zUlBRtzSLpISalqDqouEKcimkaiGnp-jjWHfruscefKg22qv4A2mh630VK4q84PS_kBSMYpqXEZ6NcC0NVNq2XXBSrcGCk6az0Or4fEkozTArhrrpAR5XAxutDvlPez6SAL_DWvbeVzd3346mq_uj6efFsZQvlnv07BBVnTGwhio2cr7a4xcjV67z3kFbbZ3eSPdUEVwNI1xNI1xNMxkz3k9N6esNNP_8Lv5hikuvpGmdtEr7HWN5RgQfWvZuZA8-dG4XzjjHrBT0L5zO_wI</recordid><startdate>19921218</startdate><enddate>19921218</enddate><creator>Yang, Guang</creator><creator>Masland, Richard H.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19921218</creationdate><title>Direct Visualization of the Dendritic and Receptive Fields of Directionally Selective Retinal Ganglion Cells</title><author>Yang, Guang ; Masland, Richard H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c714t-c8b3d1e0f8094437334e744c988933751639bf321e07eb37ecb6d8ce5a9acfe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Action potentials</topic><topic>Amacrine cells</topic><topic>Amidines</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Dendrites</topic><topic>Dendrites - physiology</topic><topic>Dendrites - ultrastructure</topic><topic>Electrodes</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Eye Movements</topic><topic>Fluorescent Dyes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia</topic><topic>Neurons</topic><topic>Optic Nerve - physiology</topic><topic>Photoreceptors</topic><topic>Rabbits</topic><topic>Retina</topic><topic>Retinal Ganglion Cells - cytology</topic><topic>Retinal Ganglion Cells - physiology</topic><topic>Retinal images</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Guang</creatorcontrib><creatorcontrib>Masland, Richard H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Biography (Gale in Context)</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Canada</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Guang</au><au>Masland, Richard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct Visualization of the Dendritic and Receptive Fields of Directionally Selective Retinal Ganglion Cells</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1992-12-18</date><risdate>1992</risdate><volume>258</volume><issue>5090</issue><spage>1949</spage><epage>1952</epage><pages>1949-1952</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Optical methods were used to locate the cell bodies of directionally selective ganglion cells in isolated rabbit retinas. These neurons detect the direction in which images move across the retinal surface and transmit that information to the brain. The receptive field of each identified cell was determined, after which the cell was injected with Lucifer yellow. An image of the receptive field border was then projected onto the fluorescent image of the dendrites, allowing precise comparison between them. The size of the receptive field matched closely the size of the dendritic arbor of that cell. This result restricts the types of convergence that can be postulated in modeling the mechanism of retinal directional selectivity.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>1470920</pmid><doi>10.1126/science.1470920</doi><tpages>4</tpages></addata></record>
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source	American Association for the Advancement of Science; JSTOR Archival Journals and Primary Sources Collection; Social Science Premium Collection; Education Collection
subjects	Action potentials Amacrine cells Amidines Animals Biological and medical sciences Cell physiology Dendrites Dendrites - physiology Dendrites - ultrastructure Electrodes Eye and associated structures. Visual pathways and centers. Vision Eye Movements Fluorescent Dyes Fundamental and applied biological sciences. Psychology Ganglia Neurons Optic Nerve - physiology Photoreceptors Rabbits Retina Retinal Ganglion Cells - cytology Retinal Ganglion Cells - physiology Retinal images Vertebrates: nervous system and sense organs
title	Direct Visualization of the Dendritic and Receptive Fields of Directionally Selective Retinal Ganglion Cells
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