Amphiphilic comblike polymers enhance the colloidal stability of Fe(3)O(4) nanoparticles

Stable colloidal dispersions of magnetite (Fe(3)O(4)) nanoparticles (MNPs) were obtained with the inclusion of an amphiphilic comblike polyethylene glycol derivative (CL-PEG) as an amphiphilic polymeric surfactant. Both the size and morphology of the resulting CL-PEG-modified MNPs could be controlle...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2010-03, Vol.76 (1), p.236-240
Main Authors: Kim, Myeongjin, Jung, Jaeyeon, Lee, Jonghwan, Na, Kyunga, Park, Subeom, Hyun, Jinho
Format: Article
Language:English
Subjects:
Cell Survival - drug effects
Colloids - chemistry
Drug Carriers - chemistry
Drug Carriers - pharmacology
Drug Stability
Ferric Compounds - chemistry
Fibroblasts - drug effects
Humans
Metal Nanoparticles - chemistry
Microscopy, Electron, Transmission
Molecular Structure
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Spectroscopy, Fourier Transform Infrared
Water - chemistry
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Summary:Stable colloidal dispersions of magnetite (Fe(3)O(4)) nanoparticles (MNPs) were obtained with the inclusion of an amphiphilic comblike polyethylene glycol derivative (CL-PEG) as an amphiphilic polymeric surfactant. Both the size and morphology of the resulting CL-PEG-modified MNPs could be controlled and were characterized by transmission electron microscopy (TEM). The interaction between MNPs and CL-PEG was confirmed by the presence of characteristic infrared absorption peaks, and the colloidal stability of the nanoparticle dispersion in water was evaluated by long-term observation of the dispersion using UV-visible spectroscopy. SQUID measurements confirmed the magnetization of CL-PEG-modified MNPs. The zeta potential of the CL-PEG-modified MNPs showed a dramatic conversion from positive to negative in response to the pH of the surrounding aqueous medium due to the presence of carboxyl groups at the surface. These carboxyl groups can be used to functionalize the MNPs with biomolecules for biotechnological applications. However, regardless of surface electrostatics, the flexible, hydrophilic side chains of CL-PEG-modified MNPs prevented the approach of adjacent nanoparticles, thereby resisting aggregation and resulting in a stable aqueous colloid. The cytotoxicity of MNPs and CL-PEG-modified MNPs was evaluated by a MTT assay.
ISSN:1873-4367
DOI:10.1016/j.colsurfb.2009.10.042