Plasma Level of Platelet-Derived Microparticles Is Associated with Coronary Heart Disease Risk Score in Healthy Men

Aim: The aim of this study was to clarify the relationship between platelet-derived microparticles (PDMPs) and the Framingham 10-yr coronary heart disease (CHD) risk score. Methods: A cross-sectional study of healthy volunteers free of medication, and cardiovascular or cerebrovascular disease was co...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2010, Vol.17(4), pp.342-349
Main Authors: Ueba, Tetsuya, Nomura, Shosaku, Inami, Norihito, Nishikawa, Tomofumi, Kajiwara, Motohiro, Iwata, Ryoichi, Yamashita, Kohsuke
Format: Article
Language:English
Subjects:
Adult
Aged
Atherothrombosis
Blood Coagulation - physiology
Blood Platelets - metabolism
C-Reactive Protein - metabolism
Cell-Derived Microparticles
Coronary Disease - blood
Coronary Disease - etiology
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Framingham coronary heart disease risk score
High sensitivity CRP
Humans
Hypertension - blood
Hypertension - complications
Male
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Middle Aged
Platelet Glycoprotein GPIb-IX Complex - metabolism
Platelet-derived microparticle
Risk Factors
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Summary:Aim: The aim of this study was to clarify the relationship between platelet-derived microparticles (PDMPs) and the Framingham 10-yr coronary heart disease (CHD) risk score. Methods: A cross-sectional study of healthy volunteers free of medication, and cardiovascular or cerebrovascular disease was conducted. The subjects were 190 Japanese men (median age 41). An ELISA kit and monoclonal antibodies against CD42b and CD42a (glycoprotein Ib and IX) were used. Results: PDMPs are correlated with platelet count, high sensitivity C-reactive protein (hsCRP), and diastolic blood pressure by multivariate analysis (R2=0.316, p
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.2964