Early monitoring of external radiation therapy by [18 F]-fluoromethylcholine positron emission tomography and 3-T proton magnetic resonance spectroscopy: an experimental study in a rodent rhabdomyosarcoma model

Abstract Purpose To assess early radiation therapy (RT)-induced variations in total choline (tCho) concentration measured by proton magnetic resonance spectroscopy (H-MRS) and in18 F-labelled fluoromethylcholine (FCH) uptake measured by PET in a rodent tumour model. Methods Nine rats bearing syngeni...

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Published in:Nuclear medicine and biology 2010-07, Vol.37 (5), p.645-653
Main Authors: Rommel, Denis, Abarca-Quinones, Jorge, Bol, Anne, Peeters, Frank, Lhommel, Renaud, Lonneux, Max, Labar, Daniel, Gregoire, Vincent, Duprez, Thierry
Format: Article
Language:English
Subjects:
Alginates - metabolism
Animals
Biological and medical sciences
Biological Transport
Choline - analogs & derivatives
Choline - metabolism
Dermatology
Disease Models, Animal
Diseases of the osteoarticular system
Glucuronic Acid - metabolism
H-MRS
Hexuronic Acids - metabolism
Irradiation
Magnetic Resonance Spectroscopy - methods
Male
Medical sciences
PET
Positron-Emission Tomography
Protons
Radiology
Rats
Rhabdomyosarcoma - diagnostic imaging
Rhabdomyosarcoma - metabolism
Rhabdomyosarcoma - pathology
Rhabdomyosarcoma - radiotherapy
Rodent
Survival Rate
Therapeutic monitoring
Time Factors
Treatment Outcome
Tumors of striated muscle and skeleton
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Abstract Purpose To assess early radiation therapy (RT)-induced variations in total choline (tCho) concentration measured by proton magnetic resonance spectroscopy (H-MRS) and in18 F-labelled fluoromethylcholine (FCH) uptake measured by PET in a rodent tumour model. Methods Nine rats bearing syngenic rhabdomyosarcoma grafts in both thighs were irradiated (13 Gy, one fraction). H-MRS data and FCH-PET were acquired in the same imaging session prior to and 3, 9 and 16 days after external RT. Total choline concentration was expressed in arbitrary units as the area under the curve of the 3.2-ppm peak on H-MR spectra. FCH uptake was expressed as maximum standardized uptake value (SUVmax ) and as the % of injected dose per gram (%ID/g) after precise tumour delineation on hybrid PET-MR images. Pre- and post-RT data were compared using the Student's paired t test, and results were expressed as mean±S.D. Results Seventeen tumours were available for analysis. A mean drop in choline concentration of 45% was observed 3 days after irradiation ( P
ISSN:0969-8051
1872-9614
DOI:10.1016/j.nucmedbio.2010.03.005