Oral metastasis from primary transitional cell carcinoma of the renal pelvis: report of a case

Abstract Transitional cell carcinoma of the renal pelvis is initially a slow growing tumor arising from the transitional epithelium of the mucous membrane of the renal pelvis. Recurrences occur in two forms: superficial bladder cancer and distant metastases. The common metastasis is in the lung, liv...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2010-07, Vol.39 (7), p.737-739
Main Authors: Zhang, Y, Gu, Z.-Y, Tian, Z, Yang, C, Cai, X.-Y
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - secondary
Chemotherapy, Adjuvant
Dentistry
Fatal Outcome
Follow-Up Studies
Humans
Kidney Neoplasms - pathology
Kidney Pelvis - pathology
Lung Neoplasms - secondary
Male
Medical sciences
Mouth Neoplasms - secondary
Neoadjuvant Therapy
Neoplasm Recurrence, Local - pathology
Nephrectomy
Otorhinolaryngology. Stomatology
Radiotherapy, Adjuvant
Surgery
Ureter - surgery
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Summary:Abstract Transitional cell carcinoma of the renal pelvis is initially a slow growing tumor arising from the transitional epithelium of the mucous membrane of the renal pelvis. Recurrences occur in two forms: superficial bladder cancer and distant metastases. The common metastasis is in the lung, liver, brain and bone. Oral metastasis is seldom reported. The authors report an unusual case of transitional cell carcinoma of the renal pelvis metastasized to the oral cavity and lung simultaneously in a 74-year-old man, which occurred 1 year after a left nephroureterectomy. The patient underwent six courses of chemotherapy (gemcitabine, oxaliplatin, fluorouracil and nedaplatin), and received radiotherapy for the oral lesion. The symptoms were alleviated, but the tumor recurred in the oral cavity 2 years later. Brain and liver metastases were confirmed by CT. Repeated radiotherapy for oral metastasis was performed, but the patient died 4 years after the initial nephroureterectomy due to multiple metastases.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2010.02.018