Effect of epidural dexmedetomidine on intraoperative awareness and post-operative pain after one-lung ventilation

Background: During combined general and regional anaesthesia, it is difficult to use autonomic signs to assess whether wakefulness is suppressed adequately. We compared the effects of a dexmedetomidine–bupivacaine mixture with plain bupivacaine for thoracic epidural anaesthesia on intraoperative awa...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2010-07, Vol.54 (6), p.703-709
Main Authors: ELHAKIM, M., ABDELHAMID, D., ABDELFATTACH, H., MAGDY, H., ELSAYED, A., ELSHAFEI, M.
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - administration & dosage
Adrenergic alpha-Agonists - pharmacology
Adrenergic alpha-Agonists - therapeutic use
Adult
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - pharmacology
Analgesics, Non-Narcotic - therapeutic use
Anesthesia
Anesthesia, Epidural
Anesthesia, General
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Inhalation - administration & dosage
Anesthetics, Inhalation - adverse effects
Anesthetics, Inhalation - pharmacology
Awareness - drug effects
Biological and medical sciences
Bupivacaine - administration & dosage
Consciousness Monitors
Dexmedetomidine - administration & dosage
Dexmedetomidine - pharmacology
Dexmedetomidine - therapeutic use
Hemodynamics - drug effects
Humans
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - pharmacology
Hypnotics and Sedatives - therapeutic use
Hypoxia - chemically induced
Hypoxia - prevention & control
Intraoperative Complications - epidemiology
Intraoperative Complications - prevention & control
Isoflurane - administration & dosage
Isoflurane - adverse effects
Isoflurane - pharmacology
Male
Medical sciences
Middle Aged
Pain, Postoperative - drug therapy
Pain, Postoperative - prevention & control
Respiration, Artificial - methods
Single-Blind Method
Thoracic Surgical Procedures
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Summary:Background: During combined general and regional anaesthesia, it is difficult to use autonomic signs to assess whether wakefulness is suppressed adequately. We compared the effects of a dexmedetomidine–bupivacaine mixture with plain bupivacaine for thoracic epidural anaesthesia on intraoperative awareness and analgesic benefits, when combined with superficial isoflurane anaesthesia (
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.2009.02199.x