Neonatal renal vein thrombosis and prothrombotic risk

A case of extensive deep venous thrombosis in a four a day old infant was presented. Unusually this patient was shown to be heterozygous for three thrombophilia genes; Factor V Leiden, prothrombin and antithrombin gene mutations, the latter being novel. Conclusion:  There are no randomized controlle...

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Bibliographic Details
Published in:Acta Paediatrica 2010-07, Vol.99 (7), p.1104-1107
Main Authors: Harris, SL, Smith, MP, Laurie, A, Darlow, BA
Format: Article
Language:English
Subjects:
Antithrombin gene mutation
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Epidemiology
General aspects
Humans
Infant, Newborn
Low molecular weight heparin
Medical sciences
Mutation
Newborn infant
Prothrombin - genetics
Prothrombotic risk factors
Public health. Hygiene
Public health. Hygiene-occupational medicine
Renal vein thrombosis
Renal Veins - diagnostic imaging
Risk Factors
Ultrasonography
Venous Thrombosis - diagnosis
Venous Thrombosis - genetics
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Summary:A case of extensive deep venous thrombosis in a four a day old infant was presented. Unusually this patient was shown to be heterozygous for three thrombophilia genes; Factor V Leiden, prothrombin and antithrombin gene mutations, the latter being novel. Conclusion:  There are no randomized controlled trials to guide management in deep venous thrombosis in the newborn but knowledge of the prothrombotic risk factors may help direct treatment.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2010.01717.x