Polyomavirus infection in a free-ranging California sea lion (Zalophus californianus) with intestinal T-cell lymphoma

An adult female California sea lion (Zalophus californianus) that stranded in central California was found to have a small glossal polypoid mass on gross necropsy. Histologically, the mass was consistent with a fibropapilloma, and intranuclear inclusions were found within endothelial cells lining sm...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2010-07, Vol.22 (4), p.628-632
Main Authors: Colegrove, Kathleen M, Wellehan, James F.X. Jr, Rivera, Rebecca, Moore, Peter F, Gulland, Frances M.D, Lowenstine, Linda J, Nordhausen, Robert W, Nollens, Hendrik H
Format: Article
Language:English
Subjects:
adult animals
Animals
case studies
disease diagnosis
electron microscopy
Female
females
genomics
histology
Intestinal Neoplasms - diagnosis
Intestinal Neoplasms - pathology
Intestinal Neoplasms - veterinary
intestines
lymphoma
Lymphoma, T-Cell - diagnosis
Lymphoma, T-Cell - pathology
Lymphoma, T-Cell - veterinary
nucleotide sequences
Polyomavirus
Polyomavirus - isolation & purification
Polyomavirus Infections - veterinary
Polyomavirus Infections - virology
rolling circle amplification
Sea Lions
sequence analysis
T-lymphocytes
Tumor Virus Infections - veterinary
Tumor Virus Infections - virology
viral diseases of animals and humans
wildlife diseases
Zalophus
Zalophus californianus
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Summary:An adult female California sea lion (Zalophus californianus) that stranded in central California was found to have a small glossal polypoid mass on gross necropsy. Histologically, the mass was consistent with a fibropapilloma, and intranuclear inclusions were found within endothelial cells lining small arterioles within the mass. Electron microscopy revealed 40-nm virions within endothelial intranuclear inclusions. Rolling circle amplification was used to obtain a partial viral genomic sequence. Sequence analysis identified the virus as a novel polyomavirus, tentatively named California sea lion polyomavirus 1. In addition, the sea lion had a severely thickened small intestine and swollen pale kidneys on gross examination. Severe renal amyloidosis with chronic interstitial nephritis was diagnosed histologically as well as T-cell intestinal lymphoma, which was confirmed via immunophenotyping and molecular clonality. The relationship, if any, between polyomavirus infection and the other disease processes in this sea lion is not known, but it is considered unlikely that the polyomavirus induced the lymphoma.
ISSN:1040-6387
1943-4936
DOI:10.1177/104063871002200422