Schisanwilsonins A–G and related anti-HBV lignans from the fruits of Schisandra wilsoniana

Seven new dibenzocyclooctane lignans, schisanwilsonins A–G (1–7), were isolated from the fruits of Schisandra wilsoniana, together with five known lignans (8–12). The structures of these new compounds were elucidated by spectroscopic methods including 2D-NMR techniques. The 12 lignans were tested fo...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2009-09, Vol.19 (17), p.4958-4962
Main Authors: Ma, Wen-Hui, Lu, Yan, Huang, Hai, Zhou, Pei, Chen, Dao-Feng
Format: Article
Language:English
Subjects:
Anti-HBV
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cyclooctanes - chemistry
Fruit - chemistry
General pharmacology
Hepatitis B e Antigens - metabolism
Hepatitis B Surface Antigens - metabolism
Hepatitis B virus
Hepatitis B virus - drug effects
Humans
Lignan
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Schisandra
Schisandra - chemistry
Schisandra wilsoniana
Schisanwilsonin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Seven new dibenzocyclooctane lignans, schisanwilsonins A–G (1–7), were isolated from the fruits of Schisandra wilsoniana, together with five known lignans (8–12). The structures of these new compounds were elucidated by spectroscopic methods including 2D-NMR techniques. The 12 lignans were tested for anti-hepatitis B virus (HBV) activity in vitro. Schisanwilsonin D (4), schisantherin C (9), deoxyschizandrin (10) and (+)-gomisin K 3 (11) showed anti-HBV activity. 9 exhibited the most potent anti-HBV activity with potency against HBsAg and HBeAg secretion by 59.7% and 34.7%, respectively, at 50 μg/mL.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2009.07.078