Indications for combined liver and kidney transplantation in children

:  A significant number of patients awaiting liver transplantation have associated renal failure and renal dysfunction is associated with increased morbidity and mortality after LT. There has been a recent increase in the number of CLKT in adults. The common indications for CLKT in children are diff...

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Bibliographic Details
Published in:Pediatric transplantation 2009-09, Vol.13 (6), p.661-669
Main Authors: Chava, Srinivas P., Singh, Balbir, Pal, Sujoy, Dhawan, Anil, Heaton, Nigel D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
combined transplantation
General aspects
Graft Survival
Humans
Hyperoxaluria, Primary - therapy
Incidence
Kidney - abnormalities
Kidney Diseases - surgery
Kidney Diseases - therapy
kidney transplantation
Kidney Transplantation - methods
Liver - abnormalities
Liver Diseases - surgery
Liver Diseases - therapy
liver transplantation
Liver Transplantation - methods
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Methylmalonyl-CoA Mutase - deficiency
pediatric transplantation
Pediatrics - methods
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Surgery of the urinary system
Treatment Outcome
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Summary::  A significant number of patients awaiting liver transplantation have associated renal failure and renal dysfunction is associated with increased morbidity and mortality after LT. There has been a recent increase in the number of CLKT in adults. The common indications for CLKT in children are different from those of adults and include metabolic diseases affecting the kidney with or without liver dysfunction and congenital developmental abnormalities affecting both organs. The results are generally encouraging among these groups of patients. Early evaluation and listing of patients before they become severely ill or have major systemic manifestations of their metabolic problem are important.
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2008.01046.x