Mortality in pediatric renal transplantation: A study of the French pediatric kidney database

:  Objective and Methods:  To assess patient survival in pediatric renal transplantation, we retrospectively reviewed 573 transplants in 553 patients, registered from 1995 to 2005. Results:  Mean age at transplantation was 9.9 years. Patient survival at 1, 5 and 10 years was respectively 99%, 97% an...

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Bibliographic Details
Published in:Pediatric transplantation 2009-09, Vol.13 (6), p.725-730
Main Authors: Allain-Launay, E., Roussey-Kesler, G., Ranchin, B., Guest, G., Maisin, A., Novo, R., André, J. L., Cloarec, S., Guyot, C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
children
Databases, Factual
Epidemiology
France
General aspects
Graft Rejection - mortality
Humans
Immunosuppressive Agents - therapeutic use
Kidney Diseases - mortality
Kidney Diseases - surgery
Kidney Diseases - therapy
Kidney Transplantation - adverse effects
Kidney Transplantation - methods
Medical sciences
mortality
Public health. Hygiene
Public health. Hygiene-occupational medicine
Registries
Renal Dialysis
renal transplantation
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
Treatment Outcome
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Summary::  Objective and Methods:  To assess patient survival in pediatric renal transplantation, we retrospectively reviewed 573 transplants in 553 patients, registered from 1995 to 2005. Results:  Mean age at transplantation was 9.9 years. Patient survival at 1, 5 and 10 years was respectively 99%, 97% and 96%. Death occurred at a median time of 2.6 years after transplantation. Long‐term patient survival was significantly lower in recipients younger than 5 years old. Seventeen patients (3.1%) died. Two deaths occurred while under maintenance dialysis. Among the remaining patients, the two main causes of death were infections (33%) and malignancies (27%). Interestingly, initial disease‐related complications were a major cause of death (34%). Conclusion:  A low mortality rate was observed, with the majority of deaths due to malignancies and infections, and with a notable participation of complications related to the initial disease. No impact of cardiovascular disease was noted with the given follow‐up period. Improvements in managing immunosuppression may contribute to reducing mortality in pediatric renal transplantation.
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2009.01036.x