Evaluating different PrP genotype selection strategies for expected severity of scrapie outbreaks and genetic progress in performance in commercial sheep

Stochastic computer simulations were used for quantifying the effect of selecting on prion protein (PrP) genotype on the risk of major outbreaks of classical scrapie and the rate of genetic progress in performance in commercial sheep populations already undergoing selection on performance. The risk...

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Bibliographic Details
Published in:Preventive veterinary medicine 2009-10, Vol.91 (2-4), p.161-171
Main Authors: Man, W.Y.N., Nicholls, N., Woolhouse, M.E.J., Lewis, R.M., Villanueva, B.
Format: Article
Language:English
Subjects:
alleles
Animals
ARR allele
Basic reproductive ratio
computer analysis
disease outbreaks
Disease Outbreaks - veterinary
disease severity
Female
Gene Frequency
Genotype
Male
Models, Statistical
Monte Carlo Method
prions
PrP genotype
PrP genotypes
PrP selection
PrPSc Proteins - genetics
PrPSc Proteins - pathogenicity
risk assessment
Scrapie
Scrapie - epidemiology
Scrapie - genetics
sheep
Sheep - genetics
Sheep Diseases - epidemiology
stochastic processes
VRQ allele
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Summary:Stochastic computer simulations were used for quantifying the effect of selecting on prion protein (PrP) genotype on the risk of major outbreaks of classical scrapie and the rate of genetic progress in performance in commercial sheep populations already undergoing selection on performance. The risk of a major outbreak on a flock was measured by the basic reproduction ratio (R0). The effectiveness of different PrP selection strategies for reducing the population risk was assessed by the percentage of flocks with R0
ISSN:0167-5877
1873-1716
DOI:10.1016/j.prevetmed.2009.05.025