Interaction between parathyroid hormone and the Charlson comorbidity index on survival of incident haemodialysis patients

Background. Haemodialysis patients are ageing and have with a high rate of comorbidities. The impact of this novel clinical setting on intact parathyroid hormone (iPTH) is not well established. Methods. For this observational, prospective multicentre cohort study, incident haemodialysis patients wer...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2009-09, Vol.24 (9), p.2859-2865
Main Authors: Morrone, Luigi Francesco, Mazzaferro, Sandro, Russo, Domenico, Aucella, Filippo, Cozzolino, Mario, Facchini, Maria Grazia, Galfrè, Andrea, Malberti, Fabio, Mereu, Maria Cristina, Nordio, Maurizio, Pertosa, Giovanni, Santoro, Domenico
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Charlson index
Cohort Studies
Comorbidity
elderly
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
incident ESRD patients
intact parathyroid hormone
Intensive care medicine
Italy - epidemiology
Kaplan-Meier Estimate
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - therapy
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Parathyroid Hormone - blood
Prospective Studies
Renal Dialysis - mortality
Renal failure
survival
Young Adult
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Summary:Background. Haemodialysis patients are ageing and have with a high rate of comorbidities. The impact of this novel clinical setting on intact parathyroid hormone (iPTH) is not well established. Methods. For this observational, prospective multicentre cohort study, incident haemodialysis patients were recruited in 40 Italian centres and followed up for a mean period of 18 ± 6.7 months. Clinical characteristics and biochemistry were recorded at baseline. Comorbid conditions were scored by the Charlson comorbidity index (CCI). Results. Data of 411 patients (mean age: 66.5 ± 14.8 years; 17.3% >80 years old) were recorded. The mean CCI was 4.17 ± 2.8. In patients with CCI >0, an inverse correlation was observed between CCI (excluding age) and iPTH (P = 0.00002). Independently of CCI, patients with iPTH
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfp170