Long-term effects of prostaglandin analogues on the anterior chamber depth of patients with primary open-angle glaucoma

• Published in: Cutaneous and ocular toxicology 2009, Vol.28 (3), p.125-128
• Main Authors: im ek, aban, Yülek, Fatma, Çakmak, Hasan Basri, Midillio lu, nci Koçak
• Format: Article
• Language: English
• Subjects: Adult; Aged; Amides - administration & dosage; Amides - adverse effects; Amides - therapeutic use; Anterior Chamber - diagnostic imaging; Anterior Chamber - drug effects; Bimatoprost; Cloprostenol - administration & dosage; Cloprostenol - adverse effects; Cloprostenol - analogs & derivatives; Cloprostenol - therapeutic use; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Glaucoma, Open-Angle - drug therapy; Humans; Male; Middle Aged; Prostaglandins F, Synthetic - administration & dosage; Prostaglandins F, Synthetic - adverse effects; Prostaglandins F, Synthetic - therapeutic use; Statistics, Nonparametric; Time Factors; Treatment Outcome; Ultrasonography
• ISSN: 1556-9527; 1556-9535
• DOI: 10.1080/15569520903155701

Objective: To evaluate the effect of long-term application of bimatoprost and latanoprost on the anterior chamber depth of primary open-angle glaucoma patients. Methods: The anterior chamber depth (ACD) and axial length (AL) of patients using prostaglandin analogues for open-angle glaucoma (group I) and an age- and gender-adjusted control group (group II) were measured by ultrasonography. Patients using bimatoprost and those using latanoprost were also compared in terms of ACD and AL. Results: The mean ACD of group I (27 eyes of 27 subjects) was significantly lower than that of group II (30 eyes of 30 subjects) (p = .012). Similarly, the ratio of ACD to AL was significantly lower in group I compared with group II (p = .001). The ACDs of patients using bimatoprost or latanoprost and the control group were not significantly different by Kruskal-Wallis test (p = .056), but the differences of these 3 groups in ACD/AL ratios were significant (p = .004). When the Mann Whitney U test was used for pairwise comparison, there was a significant difference between the control group and the patients using latanoprost or bimatoprost in terms of the ACD/AL ratio (p = .008 for each). There was no difference between the patients using latanoprost and those using bimatoprost in terms of the ACD/AL ratio (p = .4). Conclusion: The ACD of patients on prolonged therapy with prostaglandin analogues seems to be lower than than that of the control group. However, prospective long-term studies on large number of subjects are needed to evaluate the effect of each type of prostaglandin on ocular structures.