Neoplastic pleocytosis in a dog with metastatic mammary carcinoma and meningeal carcinomatosis

: A 12‐year‐old female spayed Labrador Retriever was presented with a history of seizures and abnormal vocalization. Approximately 1 year before presentation, multiple mammary cysts had been surgically excised. A mammary mass was noted on physical examination, and 2 separate parenchymal brain lesion...

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Bibliographic Details
Published in:Veterinary clinical pathology 2010-06, Vol.39 (2), p.247-252
Main Authors: Behling‐Kelly, Erica, Petersen, Sophie, Muthuswamy, Anantharaman, Webb, Julie L., Young, Karen M.
Format: Article
Language:English
Subjects:
Animals
Canine
cerebrospinal fluid
Diagnosis, Differential
Dog Diseases - cerebrospinal fluid
Dog Diseases - diagnosis
Dog Diseases - pathology
Dogs
Female
Leukocytosis - pathology
Leukocytosis - veterinary
mammary carcinoma
Mammary Neoplasms, Animal - cerebrospinal fluid
Mammary Neoplasms, Animal - diagnosis
Mammary Neoplasms, Animal - pathology
meningeal carcinomatosis
Meningeal Carcinomatosis - cerebrospinal fluid
Meningeal Carcinomatosis - pathology
Meningeal Carcinomatosis - veterinary
Neoplasm Metastasis
pleocytosis
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Summary:: A 12‐year‐old female spayed Labrador Retriever was presented with a history of seizures and abnormal vocalization. Approximately 1 year before presentation, multiple mammary cysts had been surgically excised. A mammary mass was noted on physical examination, and 2 separate parenchymal brain lesions were found on imaging studies. Cerebrospinal fluid (CSF) collected from the cisterna magna was analyzed, and abnormalities included moderate pleocytosis with atypical discrete round cells that occasionally formed loose clusters. The dog was euthanized, and on necropsy a primary solid mammary carcinoma was identified as well as multiple metastatic foci in the brain with diffuse meningeal involvement. The cells in the CSF had a morphologic appearance similar to the cells in the primary mammary tumor and in the metastatic tumors in the brain. On immunostaining, cells from the primary mammary tumor, the brain tumors, and the CSF expressed cytokeratin. The CSF cells did not express CD18, CD3, or CD79a. A final diagnosis of mammary carcinoma with brain metastasis and meningeal carcinomatosis was made.
ISSN:0275-6382
1939-165X
DOI:10.1111/j.1939-165X.2009.00211.x