Mortality trend from sporadic Creutzfeldt-Jakob disease (CJD) in Italy, 1993–2000

The objective was to identify any possible cases of variant Creutzfeldt-Jakob disease (CJD) in Italy, and to estimate the trends in mortality from sporadic CJD for 1993–2000. CJD cases were ascertained through direct notification to the Registry; 382 definite or probable sporadic CJD patients, but n...

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Bibliographic Details
Published in:Journal of clinical epidemiology 2003-05, Vol.56 (5), p.494-499
Main Authors: Puopolo, Maria, Ladogana, Anna, Almonti, Susanna, Daude, Nathalie, Bevivino, Simona, Petraroli, Rosella, Poleggi, Anna, Quanguo, Liu, Pocchiari, Maurizio
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Age groups
Aged
Aged, 80 and over
Biological and medical sciences
Confidence intervals
Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease (CJD)
Creutzfeldt-Jakob Syndrome - epidemiology
Creutzfeldt-Jakob Syndrome - genetics
Creutzfeldt-Jakob Syndrome - mortality
Databases, Factual
Diagnosis, Differential
Epidemiology
Female
Human viral diseases
Humans
Incidence
Infectious diseases
Italy - epidemiology
Male
Medical sciences
Middle Aged
Molecular genetic
Mortality
Mortality rate
Nation-wide surveillance
Population Surveillance
Regression Analysis
Sex Distribution
Statistics, Nonparametric
Surveillance
Transmissible spongiform encephalopathy (TSE)
Trends
Viral diseases
Viral diseases of the nervous system
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Items that cite this one
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Summary:The objective was to identify any possible cases of variant Creutzfeldt-Jakob disease (CJD) in Italy, and to estimate the trends in mortality from sporadic CJD for 1993–2000. CJD cases were ascertained through direct notification to the Registry; 382 definite or probable sporadic CJD patients, but no cases of variant CJD were identified. The average yearly mortality rate was 1.04 cases per million inhabitants, with an increase in deaths in the 60–69 and ⩾70 year age groups. Survival was shorter in male respect to female and in patients with an age at onset ⩾65 years. CJD cases were uneven distributed among different regions in the period 1993–1995, but not herein after. The rise in mortality from sporadic CJD in Italy likely reflects increased awareness and better diagnosis during the years. However, continuous notification and postmortem examination of all suspected cases are recommended for optimal surveillance.
ISSN:0895-4356
1878-5921
DOI:10.1016/S0895-4356(02)00606-6